8018-01-7
8018-01-7
Chemical Structure
Mancozeb
- CAS No.: 8018-01-7
- Formula:C8H12Mn2N4S8Zn22-
- Molecular Weight:661.36
InChIKey: ZBPZDNVCARTAPW-UHFFFAOYSA-J
SMILES: S=C([S-])NCCNC1=[S][Mn]([Mn+])[S-]1.S=C([S-])NCCNC2=[S][Zn]([Zn+])[S-]2
Biological Activity: Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mancozeb | 85.50% | Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells. | ||||||||||||||||||||
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References
- [1]. Santos R, er al. Thyroid and reproductive hormones in relation to pesticide use in an agricultural population in Southern Brazil. Environ Res. 2019 Jun;173:221-231. [Content Brief]
- [2]. WENX Pirozzi AV, et al. Mancozeb, a fungicide routinely used in agriculture, worsens nonalcoholic fatty liver disease in the human HepG2 cell model. Toxicol Lett. 2016 May 13;249:1-4. [Content Brief]
- [3]. Gao N, et al. The administration of Glycyrrhiza polysaccharides mitigates liver injury in mice caused by mancozeb via the Keap1-Nrf2/NF-κB pathway. Food Chem Toxicol. 2024 Nov 4:115088. [Content Brief]
- [4]. Bao J, et al. Low level of mancozeb exposure affects ovary in mice. Ecotoxicol Environ Saf. 2022 Jul 1;239:113670. [Content Brief]
