Myosin

Myosin Related Products (84):

By Effects:	Inhibitors (57) Activators (9) Modulators (8) Control (1) Substrate (1)

Cat. No.	Product Name	Effect	Purity

HY-13441

(-)-Blebbistatin	Inhibitor	98.68%
(-)-Blebbistatin is a selective inhibitor of the ATPase activity of non-muscle myosin II.

HY-13813

Blebbistatin	Inhibitor	99.64%
Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration.

HY-109037

Mavacamten	Modulator	99.94%
Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC₅₀s of 490, 711 nM for bovine cardiac and human cardiac, respectively.

HY-100912

W-7 hydrochloride	Inhibitor	99.96%
W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca²⁺-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC₅₀ values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor and vascular relaxing activity. W-7 hydrochloride is a blocker of Kv4.3 and can be used for research of arrhythmias.

HY-14233

Omecamtiv mecarbil	Activator	99.83%
Omecamtiv mecarbil (CK-1827452) is a selective cardiac myosin activator.

HY-17681

Myosin-IN-5	Inhibitor
Myosin-IN-5 (example 3) is a selective cardiac myosin inhibitor with an IC₅₀ of 1.5 μM. Myosin-IN-5 shows much less effective in inhibiting skeletal myofibril activity (IC₅₀ of 43.4 μM). Myosin-IN-5 can be used for the study of hypertrophic cardiomyopathy (HCM) and cardiac diseases.

HY-180792

CK-571	Inhibitor
CK-571 is a potent and selective inhibitor of smooth muscle myosin-2 (SMM), with an IC₅₀ value of 86 nM. CK-571 exhibits IC₅₀ values for cardiac muscle myosin (CMM), skeletal muscle myosin (SKM), and non-muscle myosin-2A (NMM-2A) of 2.3, 42, and 0.58 μM, respectively. CK-571 can be used for research on asthma, chronic obstructive pulmonary disease, and other smooth muscle-related diseases.

HY-134248

Tubercidin 5'-triphosphate	Substrate
Tubercidin 5'-triphosphate (7-Deazaadenosine 5'-triphosphate) (Compound II) is an ATP (HY-B2176) analogue. Tubercidin 5'-triphosphate is hydrolyzable by Myosin B. Tubercidin 5'-triphosphate induces weak contraction of rabbit psoas myofibrils.

HY-139465

Aficamten	Inhibitor	99.86%
Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC₅₀ of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM).

HY-109128

Danicamtiv	Activator	99.59%
Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.

HY-120870

para-Nitroblebbistatin	Inhibitor	99.0%
para-Nitroblebbistatin is a derivative of Blebbistatin (HY-13813) and an inhibitor of myosin II. para-Nitroblebbistatin is photostable, non-cytotoxic, and non-phototoxic. para-Nitroblebbistatin can serve as an ideal substitute for Blebbistatin (HY-13813) to study the role of myosin II in physiology, development, and cell biology.

HY-Y0413

Biacetyl monoxime	Inhibitor	98.0%
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca²⁺ release.

HY-149662

TMDJ-035		99.92%
TMDJ-035 is a high-affinity, selective RyR2 inhibitor with an EC₅₀ of 0.0130 μM. TMDJ-035 reduces RyR2 protein expression without affecting action potential-induced Ca²⁺ transients. TMDJ-035 decreases ATP content and intracellular Ca²⁺ levels. TMDJ-035 inhibits arrhythmias in a CPVT mouse model carrying mutant RyR2s. TMDJ-035 has no effect on electrocardiogram parameters or cardiac systolic function. TMDJ-035 exacerbates heart failure in mouse myocardial infarction models and hypoxic cardiomyocytes by altering cardiac function, causing tissue damage, promoting inflammatory infiltration, collagen deposition, and changes in Myosin heavy chain/actin expression. TMDJ-035 can be used in studies related to heart failure, catecholaminergic polymorphic ventricular tachycardia, and arrhythmias.

HY-148799

Sevasemten	Inhibitor	99.32%
Sevasemten is an orally active, selective allosteric inhibitor of skeletal muscle myosin that protects skeletal muscle from contraction-induced injury. Sevasemten decreases muscle damage biomarkers and fibrosis while increasing muscle strength and activity in in Duchenne muscular dystrophy disease models.

HY-100932

ML-9	Inhibitor	99.86%
ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. ML-9 inhibits inhibits MLCK, PKA and PKC activity with K_i values of 4, 32 and 54 μM, respectively. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation.

HY-16690

BTS	Inhibitor	99.79%
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC₅₀s of ~5 µM for actin- and Ca²⁺-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers.

HY-111474

Para-aminoblebbistatin	Inhibitor	99.90%
Para-aminoblebbistatin is the inhibitor for myosin II. Para-aminoblebbistatin inhibits the ATPase activity of myosin II, thereby blocking the formation and contraction of the actin-myosin network. Para-aminoblebbistatin is a non-fluorescent and photostable Blebbistatin (HY-13813) derivative.

HY-Y0073

4-Hydroxyacetophenone	Activator	99.98%
4-Hydroxyacetophenone (P-hydroxyacetophenone) is a major hepatoprotective and choleretic compound found in Artemisia and Illicium plants, exhibiting antiviral and anti-inflammatory effects against hepatitis B virus. Additionally, 4-Hydroxyacetophenone inhibits cancer cell adhesion, invasion, and migration by remodeling actin. 4-Hydroxyacetophenone holds promise for research in the fields of inflammatory diseases and cancer.

HY-148516

MPH-220	Inhibitor	99.25%
MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness.

HY-107657

(+)-Blebbistatin	Inhibitor	98.17%
(+)-Blebbistatin is the inactive enantiomer of (–)-Blebbistatin. (–)-Blebbistatin is a selective inhibitor of myosin II ATPase.

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