1. Cytoskeleton
  2. Myosin
  3. MPH-220

MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness.

For research use only. We do not sell to patients.

MPH-220 Chemical Structure

MPH-220 Chemical Structure

CAS No. : 2649776-79-2

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Based on 1 publication(s) in Google Scholar

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Description

MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness[1].

In Vitro

MPH-220 (0-50 µM) inhibits Actin-activated ATPase activity in human muscle myosin samples[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MPH-220 (25-30 mg/kg, i.p. or oral gavage) reduces skeletal muscle force without cardiovascular effects in anesthetized rats[1].
MPH-220 (15 mg/kg, oral administration) improves gait functions in rats with brain injury[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Anesthetized rats[1]
Dosage: 25-30 mg/kg
Administration: Intraperitoneal injection (i.p.) or oral gavage
Result: Reduced skeletal muscle force.
Observed MPH-220 distribution in rat tissues in a time-dependent manner and a dose-dependent, few-fold accumulation in skeletal muscle.
Molecular Weight

383.46

Formula

C20H21N3O3S

CAS No.
Appearance

Solid

Color

Orange to red

SMILES

O[C@@]12C(N(C3=CC=C(N4CCOCC4)C=C3)CC2)=NC5=C(C=C(S5)C)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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MPH-220 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MPH-220
Cat. No.:
HY-148516
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