Neurokinin Receptor
NK receptor; Tachykinin receptor
There are three main classes of neurokinin receptors: NK1R (the substance P preferring receptor), NK2R, and NK3R. These tachykinin receptors belong to the class I (rhodopsin-like) G-protein coupled receptor (GPCR) family. The various tachykinins have different binding affinities to the neurokinin receptors: NK1R, NK2R, and NK3R. These neurokinin receptors are in the superfamily of transmembrane G-protein coupled receptors (GPCR) and contain seven transmembrane loops. Neurokinin-1 receptor interacts with the Gαq-protein and induces activation of phospholipase C followed by production of inositol triphosphate (IP3) leading to elevation of intracellular calcium as a second messenger. Further, cyclic AMP (cAMP) is stimulated by NK1R coupled to the Gαs-protein. The neurokinin receptors are expressed on many cell types and tissues.
Neurokinin Receptor Isoform Specific Products
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Neurokinin Receptor Inhibitors
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Neurokinin Receptor Agonists
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Neurokinin Receptor Antagonists
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Neurokinin Receptor Activator
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Neurokinin Receptor Modulators
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Neurokinin Receptor Controls
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Neurokinin Receptor Related Products (279)
Related Products (279)
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Antibodies (4)
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Neurokinin Receptor Isoform Comparison
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Esmolol
0 ImagesCat. No.: HY-B1392ACAS No.: 81147-92-4Esmolol is an ultra-short-acting cardioselective β1-adrenergic blocker. Esmolol exerts its antiarrhythmic effect by activating Neurokinin 1 Receptor. Esmolol attenuates post resuscitation myocardial dysfunction. Esmolol improves diabetic wound healing by inhibiting aldose reductase and the production of advanced glycation end products and promoting fibroblast migration. Esmolol can be used to study cardiac diseases such as arrhythmias and diabetic foot ulcers.
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Netupitant (Standard)
0 ImagesCat. No.: HY-16346RCAS No.: 290297-26-6Synonyms: CID 6451149 (Standard)Netupitant (Standard) is the analytical standard of Netupitant. This product is intended for research and analytical applications. Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK1) receptor antagonist with a Ki of 0.95 nM for hNK1 in CHO cells. Netupitant has antiemetic affect.
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SCH 206272
0 ImagesCat. No.: HY-116958CAS No.: 226915-43-1SCH 206272 is a selective antagonist of the tachykinin (NK) receptor. SCH 206272 inhibits binding at human tachykinin NK(1), NK(2), and NK(3) receptors (Ki = 1.3, 0.4, and 0.3 nM, respectively). SCH 206272 has an orally active.
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Befetupitant
0 ImagesCat. No.: HY-19670CAS No.: 290296-68-3Synonyms: Ro67-5930Befetupitant is a high-affinity, nonpeptide, competitive tachykinin 1 receptor (NK1R) antagonist.
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L-703606
0 ImagesCat. No.: HY-117216CAS No.: 144425-84-3L-703606 is a potent, selective antagonist of NK1 receptor. L-703606 can be used for study of gastric acid secretion.
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Saredutant (Standard)
0 ImagesCat. No.: HY-106910RCAS No.: 142001-63-6Synonyms: SR 48968 (Standard); SR 48968C (Standard)Saredutant (Standard) is the analytical standard of Saredutant. This product is intended for research and analytical applications. Saredutant is a selective NK2 receptor antagonist.
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Vapreotide diacetate
0 ImagesCat. No.: HY-P0061BCAS No.: 936560-75-7Synonyms: RC160 diacetate; BMY 41606 diacetateVapreotide diacetate is a neurokinin-1 (NK1) receptor antagonist, with an IC50 of 330 nM.
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Monohydroxy Netupitant-d6
0 ImagesCat. No.: HY-G0012SCAS No.: 2070015-07-3Monohydroxy Netupitant-d6 is the deuterium labeled Monohydroxy Netupitant, which is a metabolite of Netupitant.
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Fosrolapitant
0 ImagesCat. No.: HY-159842CAS No.: 2573694-38-7Fosrolapitant is a neurokinin 1 (NK1) receptor antagonist.
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Fosaprepitant dimeglumine (Standard)
0 ImagesCat. No.: HY-14407ARCAS No.: 265121-04-8Synonyms: MK-0517 (Standard); L785298 (Standard)Fosaprepitant (dimeglumine) (Standard) is the analytical standard of Fosaprepitant (dimeglumine). This product is intended for research and analytical applications. Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).
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Netupitant metabolite Monohydroxy Netupitant
0 ImagesCat. No.: HY-G0012CAS No.: 910808-12-7Synonyms: Monohydroxy NetupitantMonohydroxy Netupitant is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.
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WIN 62,577
0 ImagesCat. No.: HY-118356CAS No.: 144177-32-2WIN 62,577 is a rat-specific, but non-human, NK1 receptor antagonist. WIN 62,577 interacts with M1-M4 mAChRs and is an allosteric enhancer of acetylcholine affinity targeting the M3 receptor.
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Talnetant hydrochloride
0 ImagesCat. No.: HY-14552ACAS No.: 204519-66-4Synonyms: SB 223412 hydrochloride; SB 223412-ATalnetant (SB 223412) hydrochloride is a selective, competitive, brain-permeable NK3 receptor antagonist with a Ki of 1.4 nM in hNK-3-CHO cells. Talnetant hydrochloride is 100-fold more selective for hNK-3 relative to the hNK-2 receptor and has no affinity for hNK-1. Talnetant hydrochloride can be used in schizophrenia-related studies.
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Kassinin
0 ImagesCat. No.: HY-P0250CAS No.: 63968-82-1Kassinin is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides. It is secreted as a defense response, and is involved in neuropeptide signalling.
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Neurokinin A(4-10)
0 ImagesCat. No.: HY-P0236CAS No.: 97559-35-8Neurokinin A (4-10) is a tachykinin NK2 receptor agonist.
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MEN11467
0 ImagesCat. No.: HY-U00207CAS No.: 214487-46-4MEN11467 is a selective and orally- effective peptidomimetic tachykinin NK1 receptor antagonist.
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Tachykinin angatonist 1
0 ImagesCat. No.: HY-U00392CAS No.: 178310-77-5Tachykinin angatonist 1 is a neurokinin receptor antagonist extracted from patent US5968923, compound example 32.
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Neurokinin antagonist 1
0 ImagesCat. No.: HY-U00320CAS No.: 214487-45-3Neurokinin antagonist 1 is a Neurokinin antagonist extracted from patent WO1998045262A1.
