TGF-beta/Smad Inducer
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Amicoumacin B
0 ImagesAmicoumacin B can be produced by actinomycete, strain 04-5195T.. Amicoumacin B increases the expression of bone morphogenetic protein 2 (BMP-2). Amicoumacin B has inhibitory effect against C. violaceum (MIC = 250 µg/mL). Amicoumacin B has quorum sensing inhibitory activity, and reduces the expression of the C. violaceum operons vioA, vioB, vioD, and vioE, but increases the expression of vioC.
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Sphingosylphosphorylcholine-d7
0 ImagesSphingosylphosphorylcholine-d7 is the deuterium labeled Sphingosylphosphorylcholine (HY-132187).
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Sphingosylphosphorylcholine-d9
0 ImagesSphingosylphosphorylcholine-d9 is deuterium labeled Sphingosylphosphorylcholine.
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PXS 64
0 ImagesCat. No.: HY-181431CAS No.: 1253691-50-7PXS 64, a mannose-6-phosphate (M6P) analogue. a lipophilic prodrug of PXS 25 (HY-181430). PXS 64 is an effective anti-fibrotic agent by inhibiting the activation of latent TGF-β1. PXS64, inhibits fibrosis via TGF-β1 pathway in human lung fibroblasts. PXS 64 reduces TGFβ-mediated collagen IV, fibronectin, MCP-1, and phospho-smad2 expression in kidney cells. PXS 64 reduces collagen deposition in dermal scar fibroblasts. PXS 64 can be used for the research of chronic kidney disease, idiopathic pulmonary fibrosis, scarring.
