Soluble epoxide hydrolase Degrader
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PROTAC sEH degrader-3
0 ImagesCat. No.: HY-175392CAS No.: 3093413-94-3PROTAC sEH-degrader-3 is an sEH PROTAC degrader with an IC50 value of 5.5 nM against mouse sEH. PROTAC sEH-degrader-3 selectively degrades sEH in the cytoplasm but not in peroxisomes. PROTAC sEH-degrader-3 alleviates endoplasmic reticulum stress and acts as a cytoprotective agent. PROTAC sEH-degrader-3 can serve as a chemical probe for investigating the biological functions of sEH.
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PROTAC sEH degrader-1
0 ImagesCat. No.: HY-159494PROTAC sEH degrader-1 is a PROTAC degrader targeting soluble epoxide hydrolase (sEH) with a DC50 of 0.5 nM, and it also possesses sEH inhibitory activity. PROTAC sEH degrader-1 has an IC50 of 3.8 nM against human sEH and an IC50 of 210 nM against mouse sEH. PROTAC sEH degrader-1 relies on the ubiquitin-proteasome system to achieve target protein degradation, and it selectively degrades cytoplasmic sEH. PROTAC sEH degrader-1 rapidly reduces endoplasmic reticulum stress in cells, downregulates the phosphorylation levels of IRE1α, PERK and eIF2α, enhances cell viability, and alleviates Thapsigargin (HY-13433)-induced apoptosis. PROTAC sEH degrader-1 effectively degrades sEH in mouse liver and brown adipose tissue. PROTAC sEH degrader-1 can be used in studies related to metabolic disorders and inflammation.
