iGluR
Ionotropic glutamate receptors
iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.
AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.
iGluR Isoform Specific Products
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iGluR Inhibitors
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iGluR Agonists
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iGluR Antagonists
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iGluR Activators
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iGluR Modulators
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iGluR MDM2 Inhibitor
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iGluR Controls
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iGluR Ligand
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iGluR Related Products (818)
Related Products (818)
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Antibodies (11)
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iGluR Isoform Comparison
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(S)-Alaproclate
0 ImagesCat. No.: HY-124779CAS No.: 66171-75-3Synonyms: (S)-GEA 654; (S)-A03(S)-Alaproclate ((S)-GEA 654) is more potent than the R-(+)-enantiomer both in blocking the NMDA receptor currents in vitro and in antagonizing the cGMP increase in vivo.
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(R)-Lanicemine
0 ImagesCat. No.: HY-108235CCAS No.: 190581-71-6Synonyms: (R)-AZD6765(R)-Lanicemine ((R)-AZD6765) is the less active R-enantiomer of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects.
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GYKI 52466
0 ImagesCat. No.: HY-103234CAS No.: 102771-26-6GYKI 52466 is an orally active, highly selective and noncompetitive AMPA/kainate receptor antagonist with the IC50 values of 7.5 and 11μM, respectively. GYKI 52466 has good blood brain barrier permeability and anticonvulsant effect. GYKI 52466 can be used in Parkinson's disease research.
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Tezampanel hydrate
0 ImagesCat. No.: HY-75704ACAS No.: 317819-68-4Synonyms: LY293558 hydrate; NGX424 hydrateTezampanel (LY293558) hydrate is a potent, selective and competitive NMDA receptor antagonist. Tezampanel hydrate produces postoperative analgesia in rats. Tezampanel hydrate can be used for neuropathic pain research.
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ZD 9379 sodium
0 ImagesCat. No.: HY-106969ACAS No.: 170142-29-7ZD 9379 sodium is a competitive glycine/NMDA receptor antagonist, with an IC50 value of 75 nM (glutamate site). ZD 9379 sodium selectively antagonizes the glycine binding site (GlyB site) on the NMDA receptor, inhibiting the binding of glycine to the NMDA receptor and alleviating excitotoxicity. ZD 9379 sodium reduces the frequency of cortical spreading depression (SDs), alleviates energy depletion in the ischemic penumbra, and delays the expansion of infarction. ZD 9379 sodium reduces the infarct volume and improves neurological function in mouse models. ZD 9379 sodium can be used in studies of acute ischemic stroke, etc.
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Glycine-15N,d2
0 ImagesCat. No.: HY-Y0966S9CAS No.: 2732915-89-6Glycine-15N,d2 is the deuterium and 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
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NMDA agonist 2
0 ImagesCat. No.: HY-172121NMDA agonist 2 (compound 8d) is a potent agonist of NMDA receptor, with the EC50 of 0.034 μM for GluN1/2C. NMDA agonist 2 plays an important role in neurological and psychiatric disorders.
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β-Neuroprotectin
0 ImagesCat. No.: HY-P3319CAS No.: 127634-29-1β-Neuroprotectin is a (3H)TCP binding inhibitor with activity against NMDA-mediated neuronal cell death. β-Neuroprotectin can effectively inhibit the binding of [3H]TCP. β-Neuroprotectin provides neuroprotection at low concentrations against NMDA-induced neuronal cell death.
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Ro 04-5595 hydrochloride
0 ImagesCat. No.: HY-107696CAS No.: 64047-73-0Ro 04-5595 hydrochloride is a GluN2B-selective NMDA receptor antagonist (Ki: 31 nM).
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MNI-caged-NMDA
0 ImagesCat. No.: HY-107717CAS No.: 1227675-52-6MNI-caged-NMDA is a light-sensitive amino acid with rapid release properties suitable for use in the study of fast synaptic receptor mechanisms. MNI-caged-NMDA shows metered release of NMDA receptors, inducing rapid and sustained receptor activation in cerebellar interneurons. MNI-caged-NMDA is able to achieve rapid transient responses and generate large inward currents by local laser photolysis. The use of MNI-caged-NMDA can effectively study neurotransmitter signaling and its inhibitory effects on GABA-A receptors.
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Antidepressant agent 9
0 ImagesCat. No.: HY-170945CAS No.: 143899-90-5Antidepressant agent 9 (Compound 24) is an orally active and BBB-penetrable NMDAR and SERT inhibitor with IC50 values of 3.50 μM and 1044 nM, respectively. Antidepressant agent 9 has good metabolic stability and plasma exposure. Antidepressant agent 9 can exert antidepressant-like activity in the mouse forced swim test.
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TAS-4
0 ImagesCat. No.: HY-115860CAS No.: 794544-99-3TAS-4 is a potent and selective mGluR4 positive allosteric modulator with significant anti-Parkinson's disease activity. TAS-4 is able to show efficacy when used alone or in combination with l-DOPA. TAS-4 is able to reverse haloperidol-induced spasticity when administered alone. TAS-4 enhances the contralateral rotation behavior induced by l-DOPA in a dose-dependent manner. TAS-4 combined with low-dose l-DOPA shows anti-Parkinson's effects similar to full-dose l-DOPA without exacerbating abnormal motor side effects.
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Sapunifiram
0 ImagesCat. No.: HY-182686CAS No.: 577778-29-1Synonyms: MN19Sapunifiram is a cognitive enhancer. Sapunifiram can be used in studies related to amnesia.
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Irampanel
0 ImagesCat. No.: HY-15082CAS No.: 206260-33-5Synonyms: BIIR 561Irampanel (BIIR 561) is an AMPA receptor and voltage-dependent sodium channel blocker. Irampanel inhibits kainate-induced currents in rat cortical neurons.
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Risevistinel
0 ImagesCat. No.: HY-156634CAS No.: 2591344-26-0Synonyms: NYX-783Risevistinel (NYX-783) is a positive allosteric modulator of N-methyl-D-aspartate (NMDA) receptor. Nevadistinel can be used to inhibit cognitive impairment associated with neurodegenerative diseases, such as mild cognitive impairment, mild Alzheimer's disease, Parkinson's disease, Lewy body disease.
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P3LC7LC-P
0 ImagesCat. No.: HY-P11848P3LC7LC-P is a blood-brain barrier-permeable BRAG2 ligand with a KD of 6.14 μM. P3LC7LC-P binds to BRAG2, thereby disrupting its interaction with the GluA2 subunit of the AMPA receptor and inhibiting glutamate-induced GluA2 endocytosis. P3LC7LC-P exerts neuroprotective effects in oxygen-glucose deprivation-induced and glutamate-induced neurotoxicity models, reduces ROS accumulation and inhibits apoptosis, and reduces cerebral infarct size in a rat model of transient middle cerebral artery occlusion. P3LC7LC-P can be used for the research of ischemic stroke.
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CX516-d10
0 ImagesCat. No.: HY-10933SCAS No.: 1286653-21-1Synonyms: BDP 12-d10CX516-d10 is the deuterium labeled CX516. CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
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TDPAM02
0 ImagesCat. No.: HY-165475CAS No.: 2231101-34-9TDPAM02 is a positive allosteric modulator of AMPA receptor GluA2. TDPAM02 can specifically bind to the ligand-binding domain (LBD) of GluA2 and shows an IC50 of 1.4 nM for the GluA2 flop subtype. TDPAM02 can stabilize the activated conformation of GluA2 receptors, delay the receptor deactivation or desensitization process, maintaining the rapid excitatory synaptic transmission in the central nervous system.
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UBP710
0 ImagesCat. No.: HY-124264CAS No.: 1333111-40-2UBP710 is a selective NMDA receptor modulator. UBP710 displays greater activity in potentiating GluN2B-containing receptors than those containing GluN2A.
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L-Ibotenic acid
0 ImagesCat. No.: HY-120243CAS No.: 25690-45-3L-Ibotenic acid is a psychoactive compound found in Amanita muscaria and related mushroom species. L-Ibotenic acid is a conformationally restricted analog of the neurotransmitter glutamate, which may be activated by different conformations of L-glutamate and is a non-selective glutamate receptor agonist.
