794544-99-3
Chemical Structure
TAS-4
- CAS No.: 794544-99-3
- Formula:C12H8Cl2N2O
- Molecular Weight:267.11
IUPAC Name: N-(2,4-dichlorophenyl)picolinamide
InChIKey: ZNMWFDKCPWCBBU-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C=C1Cl)Cl)C2=NC=CC=C2
Biological Activity: TAS-4 is a potent and selective mGluR4 positive allosteric modulator with significant anti-Parkinson's disease activity. TAS-4 is able to show efficacy when used alone or in combination with l-DOPA. TAS-4 is able to reverse haloperidol-induced spasticity when administered alone. TAS-4 enhances the contralateral rotation behavior induced by l-DOPA in a dose-dependent manner. TAS-4 combined with low-dose l-DOPA shows anti-Parkinson's effects similar to full-dose l-DOPA without exacerbating abnormal motor side effects[1].
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TAS-4 | TAS-4 is a potent and selective mGluR4 positive allosteric modulator with significant anti-Parkinson's disease activity. TAS-4 is able to show efficacy when used alone or in combination with l-DOPA. TAS-4 is able to reverse haloperidol-induced spasticity when administered alone. TAS-4 enhances the contralateral rotation behavior induced by l-DOPA in a dose-dependent manner. TAS-4 combined with low-dose l-DOPA shows anti-Parkinson's effects similar to full-dose l-DOPA without exacerbating abnormal motor side effects. | |||||||||||||||||||||
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