iGluR
Ionotropic glutamate receptors
iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.
AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.
iGluR Isoform Specific Products
All Product Categories
-
iGluR Inhibitors
(133)
View all products
-
iGluR Agonists
(127)
View all products
-
iGluR Antagonists
(348)
View all products
-
iGluR Activators
(36)
View all products
-
iGluR Modulators
(93)
View all products
-
iGluR MDM2 Inhibitor
(1)
View all products
-
iGluR Controls
(6)
View all products
-
iGluR Ligands
(3)
View all products
-
iGluR Related Products (830)
Related Products (830)
-
Antibodies (11)
-
iGluR Isoform Comparison
-
D-AP5 (Standard)
0 ImagesSynonyms: D-APV (Standard); D-2-Amino-5-phosphonovaleric acid (Standard)D-AP5 (Standard) is the analytical standard of D-AP5 (HY-100714A). This product is intended for research and analytical applications. D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a Kd of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors.
-
CGP 55802A
0 ImagesCat. No.: HY-123602CAS No.: 152564-63-1CGP 55802A is a novel photoaffinity ligand for in situ labeling of NMDA receptors with high selectivity for the glutamate recognition site.
-
Argiotoxin 636
0 ImagesCat. No.: HY-169871CAS No.: 105029-41-2Argiotoxin 636 is a toxin and the non-specific, non-competitive, and potent ionotropic glutamate receptor (iGluR) antagonist. Argiotoxin 636 blocks excitatory synaptic transmission in neurons and has paralysis and muscle relaxation effects. Argiotoxin 636 can be used in the study of nervous system diseases.
-
DL-AP5 sodium (Standard)
0 ImagesCat. No.: HY-100714CRCAS No.: 1303993-72-7Synonyms: 2-APV sodium (Standard); DL-2-Amino-5-phosphonovaleric acid sodium (Standard)DL-AP5 (sodium) (Standard) is the analytical standard of DL-AP5 (sodium). This product is intended for research and analytical applications. DL-AP5 (2-APV) sodium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 sodium shows significantly antinociceptive activity. DL-AP5 sodium specifically blocks on channels in the rabbit retina.
-
DNQX (Standard)
0 ImagesDNQX (Standard) is the analytical standard of DNQX. This product is intended for research and analytical applications. DNQX (FG 9041), a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively).
-
Dizocilpine (Standard)
0 ImagesCat. No.: HY-15084BRCAS No.: 77086-21-6Synonyms: MK-801 (Standard)Dizocilpine (Standard) is the analytical standard of Dizocilpine (HY-15084B). This product is intended for research and analytical applications. Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux.
-
NBQX disodium (Standard)
0 ImagesCat. No.: HY-15068ARCAS No.: 479347-86-9Synonyms: FG9202 disodium (Standard)NBQX (disodium) (Standard) is the analytical standard of NBQX (disodium). This product is intended for research and analytical applications. NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity.
-
Dasolampanel etibutil
0 ImagesCat. No.: HY-123557CAS No.: 503291-52-9Dasolampanel etibutil is an ion-type glutamate receptor 5 (iGluR5) antagonist.
-
CX516 (Standard)
0 ImagesCat. No.: HY-10933RCAS No.: 154235-83-3Synonyms: BDP 12 (Standard)CX516 (Standard) is the analytical standard of CX516 (HY-10933). This product is intended for research and analytical applications. CX516 (BDP 12) is an ampaKine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
-
SYM 2081 (Standard)
0 ImagesCat. No.: HY-101310RCAS No.: 31137-74-3SYM 2081 (Standard) is the analytical standard of SYM 2081 (HY-101310). This product is intended for research and analytical applications. SYM 2081 is a kainate receptor agonist. SYM 2081 is a substrate of EAAT1 (Km of 54 μM). SYM 2081 inhibits EAAT2-mediated glutamate transport (Kb is 3.4 μM in Xenopus oocytes), modulates Apoptotic signaling pathways (increases Bcl-2 and decreases Bax/caspase-3 expression). SYM 2081 exhibits neuroprotective activity. SYM 2081 can be used in the study of hypoxic-ischemic brain damage and inflammatory or neuropathic pain.
-
Memantine lactose adduct
0 ImagesCat. No.: HY-137064CAS No.: 1159637-28-1Memantine lactose adduct is a lactose adduct of Memantine (HY-B0591) and an intermediate in the synthesis of adamantane amine antibiotics.
-
1H-pyrazole (Standard)
0 Images1H-pyrazole (Standard) is the analytical standard of 1H-pyrazole. This product is intended for research and analytical applications. 1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis.
-
(Rac)-NMDAR antagonist 1 (Standard)
0 ImagesCat. No.: HY-111500RCAS No.: 2435557-99-4(Rac)-NMDAR antagonist 1 (Standard) is the analytical standard of (Rac)-NMDAR antagonist 1 (HY-111500). This product is intended for research and analytical applications. (Rac)-NMDAR antagonist 1 is the racemate of NMDAR antagonist 1. NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist.
-
GNE-8324 (Standard)
0 ImagesCat. No.: HY-107498RCAS No.: 1698901-76-6GNE-8324 (Standard) is the analytical standard of GNE-8324 (HY-107498). This product is intended for research and analytical applications. GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons.
-
UBP608 (Standard)
0 ImagesCat. No.: HY-100667RCAS No.: 2199-87-3
-
LY-503430
0 ImagesCat. No.: HY-122164CAS No.: 625820-83-9LY-503430 is an orally active AMPA receptor positive allosteric modulator (PAM). LY-503430 can be used for the study of Parkinson's disease.
-
Isoxsuprine
0 ImagesIsoxsuprine is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.
-
Orphenadrine citrate (Standard)
0 ImagesOrphenadrine (citrate) (Standard) is the analytical standard of Orphenadrine (citrate). This product is intended for research and analytical applications. Orphenadrine citrate is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine citrate relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine citrate is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases.
-
TAT-GluR6-9c
0 ImagesCat. No.: HY-P10401TAT-GluR6-9c is a GluR6-PSD95 interaction blocker. By regulating the GluR6 mediated signaling pathway, TAT-GluR6-9c inhibits the activation of JNK and phosphorylation of c-Jun, reduces the expression of Fas L and thus reduces the occurrence of apoptosis. TAT-GluR6-9c can be used to study cerebral ischemia and neuroprotective strategies .
