Argiotoxin 636

Cat. No.: HY-169871: Data Sheet Handling Instructions
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Argiotoxin 636 is a toxin and the non-specific, non-competitive, and potent ionotropic glutamate receptor (iGluR) antagonist. Argiotoxin 636 blocks excitatory synaptic transmission in neurons and has paralysis and muscle relaxation effects. Argiotoxin 636 can be used in the study of nervous system diseases.

For research use only. We do not sell to patients.

Argiotoxin 636 Chemical Structure

CAS No. : 105029-41-2

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AMPA Receptor NMDA Receptor Kainate Receptor

Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
Oocyte	IC₅₀	0.23 μM Compound: ArgTx-636	Inhibition of GluA3 receptor expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay Inhibition of GluA3 receptor expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	0.23 μM Compound: ArgTx-636	Inhibition of recombinant GluA3 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay Inhibition of recombinant GluA3 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	0.35 μM Compound: ArgTx-636	Inhibition of GluA1 receptor expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay Inhibition of GluA1 receptor expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	0.35 μM Compound: ArgTx-636	Inhibition of recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay Inhibition of recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	0.43 μM Compound: ArgTx-636	Inhibition of GluA4 receptor expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay Inhibition of GluA4 receptor expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	0.43 μM Compound: ArgTx-636	Inhibition of recombinant GluA4 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay Inhibition of recombinant GluA4 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	135 nM Compound: ArgTX-636, 1	Antagonist activity at rat GluA1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology assay Antagonist activity at rat GluA1 receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology assay	[PMID: 23092360]
Oocyte	IC₅₀	177 nM Compound: ArgTX-636, 1	Antagonist activity at rat glutamate N1/2A receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology assay Antagonist activity at rat glutamate N1/2A receptor expressed in Xenopus oocytes at membrane potential -60 mV by two-electrode voltage-clamp electrophysiology assay	[PMID: 23092360]
Oocyte	IC₅₀	3.4 μM Compound: ArgTx-636	Activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as effect of 100 uM kainate-induced current by patch clamp electrophysiological assay Activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as effect of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	3.4 μM Compound: ArgTx-636	Inhibition of rat recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current Inhibition of rat recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current	[PMID: 20096591]
Oocyte	IC₅₀	300 μM Compound: ArgTx-636	Activity at recombinant GluA1A2 receptor flop isoform expressed in Xenopus oocytes assessed as effect of 100 uM kainate-induced current by patch clamp electrophysiological assay Activity at recombinant GluA1A2 receptor flop isoform expressed in Xenopus oocytes assessed as effect of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	300 μM Compound: ArgTx-636	Inhibition of rat recombinant GluA1A2 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current Inhibition of rat recombinant GluA1A2 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current	[PMID: 20096591]
Oocyte	IC₅₀	5.5 μM Compound: ArgTx-636	Inhibition of recombinant GluA1A2 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay Inhibition of recombinant GluA1A2 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiological assay	[PMID: 20096591]
Oocyte	IC₅₀	74 nM Compound: ArgTX-636	Inhibition of rat GluN1/2A expressed in xenopus laevis oocytes assessed as inhibition of glycine-evoked current at membrane potential of -60 mV by voltage-clamp electrophysiology Inhibition of rat GluN1/2A expressed in xenopus laevis oocytes assessed as inhibition of glycine-evoked current at membrane potential of -60 mV by voltage-clamp electrophysiology	[PMID: 21188966]
Oocyte	IC₅₀	77 nM Compound: ArgTX-636	Inhibition of rat GluA1 expressed in xenopus laevis oocytes assessed as inhibition of glutamate-evoked current at membrane potential of -60 mV by voltage-clamp electrophysiology Inhibition of rat GluA1 expressed in xenopus laevis oocytes assessed as inhibition of glutamate-evoked current at membrane potential of -60 mV by voltage-clamp electrophysiology	[PMID: 21188966]

Molecular Weight

636.79

Formula

C₂₉H₅₂N₁₀O₆

CAS No.

105029-41-2

SMILES

N=C(N)NCCC[C@H](N)C(NCCCNCCCNCCCCCNC([C@H](CC(N)=O)NC(CC1=C(C=C(C=C1)O)O)=O)=O)=O

Structure Classification

Initial Source

Argiope aurantia

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Adams ME, et al. Structures and biological activities of three synaptic antagonists from orb weaver spider venom. Biochem Biophys Res Commun. 1987 Oct 29;148(2):678-83. [Content Brief]

[2]. Ashe JH, et al. Argiotoxin-636 blocks excitatory synaptic transmission in rat hippocampal CA1 pyramidal neurons. Brain Res. 1989 Feb 20;480(1-2):234-41. [Content Brief]

Argiotoxin 636 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Argiotoxin 636105029-41-2Argiotoxin636Argiotoxin-636iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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Argiotoxin 636

Argiotoxin 636 Related Antibodies

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Customer Review

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