105029-41-2
105029-41-2
Chemical Structure
Argiotoxin 636
- CAS No.: 105029-41-2
- Formula:C29H52N10O6
- Molecular Weight:636.79
InChIKey: FTNICLJXPYLDAH-GOTSBHOMSA-N
SMILES: N=C(N)NCCC[C@H](N)C(NCCCNCCCNCCCCCNC([C@H](CC(N)=O)NC(CC1=C(C=C(C=C1)O)O)=O)=O)=O
Biological Activity: Argiotoxin 636 is a toxin and the non-specific, non-competitive, and potent ionotropic glutamate receptor (iGluR) antagonist. Argiotoxin 636 blocks excitatory synaptic transmission in neurons and has paralysis and muscle relaxation effects. Argiotoxin 636 can be used in the study of nervous system diseases[1][2].
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Argiotoxin 636 | Argiotoxin 636 is a toxin and the non-specific, non-competitive, and potent ionotropic glutamate receptor (iGluR) antagonist. Argiotoxin 636 blocks excitatory synaptic transmission in neurons and has paralysis and muscle relaxation effects. Argiotoxin 636 can be used in the study of nervous system diseases. | |||||||||||||||||||||
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References
- [1]. Adams ME, et al. Structures and biological activities of three synaptic antagonists from orb weaver spider venom. Biochem Biophys Res Commun. 1987 Oct 29;148(2):678-83. [Content Brief]
- [2]. Ashe JH, et al. Argiotoxin-636 blocks excitatory synaptic transmission in rat hippocampal CA1 pyramidal neurons. Brain Res. 1989 Feb 20;480(1-2):234-41. [Content Brief]
Keywords
