LY-503430
LY-503430 is an orally active AMPA receptor positive allosteric modulator (PAM). LY-503430 can be used for the study of Parkinson's disease.
For research use only. We do not sell to patients.
- CAS No.: 625820-83-9
- Formula: C20H25FN2O3S
- Molecular Weight:392.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
The submicromolar concentrations of LY-503430 (0.03-10 μM) selectively enhances glutamate-induced calcium influx into human embryonic kidney 293 cells transfected with human GLUA1, GLUA2, GLUA3, or GLUA4 AMPA receptors. LY-503430 also potentiates AMPA-mediated responses in native cortical, hippocampal, and substantia nigra neurons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57Bl6J mice (20-25 g) injected with MPTP (HY-15608)[1]
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Dosage:0.5 mg/kg
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Administration:s.c; once a day; for 11 days
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Result:Prevention of MPTP-induced neurotoxicity in mice.
Chemical Information
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CAS No. 625820-83-9
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Molecular Weight 392.49
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Formula C20H25FN2O3S
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SMILES
O=C(C1=CC=C(C2=CC=C([C@](C)(F)CNS(=O)(C(C)C)=O)C=C2)C=C1)NC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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