iGluR
Ionotropic glutamate receptors
iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.
AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.
iGluR Isoform Specific Products
All Product Categories
-
iGluR Inhibitors
(131)
View all products
-
iGluR Agonists
(131)
View all products
-
iGluR Antagonists
(348)
View all products
-
iGluR Activators
(35)
View all products
-
iGluR Modulators
(93)
View all products
-
iGluR MDM2 Inhibitor
(1)
View all products
-
iGluR Controls
(5)
View all products
-
iGluR Ligands
(3)
View all products
-
iGluR Related Products (830)
Related Products (830)
-
Antibodies (11)
-
iGluR Isoform Comparison
-
ZK 187638
0 ImagesCat. No.: HY-124539CAS No.: 397298-63-4ZK 187638 is an AMPA receptor antagonist. ZK 187638 antagonizes the kainate-induced currents in cultured hippocampal neurons with an IC50 of 3.4 μM in a noncompetitive fashion.
-
R-(+)-EU-1180-453
0 ImagesCat. No.: HY-156505ACAS No.: 2488764-06-1R-(+)-EU-1180-453 is a positive allosteric modulator targeting NMDA receptors containing GluN2C and GluN2D subunits, with a pEC50 value of 5.5 for both rat receptor subtypes, and it can cross the blood-brain barrier. R-(+)-EU-1180-453 increases the potency of glutamate, enhances receptor responses to maximally effective concentrations of agonists, and acts only on receptors bound to both co-agonists. R-(+)-EU-1180-453 is applicable to research related to Alzheimer's disease, Parkinson's disease, epilepsy, and neuropathic pain.
-
SR 57227A free base
0 ImagesCat. No.: HY-121704CAS No.: 77145-51-8SR 57227A Free base is a highly selective compound for both peripheral and central 5-HT3 receptors and acts as an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells, demonstrating antidepressant-like effects in rats while reducing isolation-induced aggressive behavior.
-
(3S,6R)-NML
0 ImagesCat. No.: HY-172213CAS No.: 1585965-04-3(3S,6R)-NML is a NMDA receptor antagonist, with pIC50s of 4.8 (GluN1-GluN2A), 4.6 (GluN1-GluN2B), 5.0 (GluN1-GluN2C), 5.0 (GluN1-GluN2D) respectively. (3S,6R)-NML can be used for depression research.
-
Conantokin-T
0 ImagesCat. No.: HY-P1287CAS No.: 127476-26-0Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC50 value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa.
-
YM928
0 ImagesCat. No.: HY-118814CAS No.: 190842-36-5YM928 is an orally active and noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist. YM928 inhibits AMPA receptor-mediated toxicity in primary rat hippocampal cultures with an IC50 value of 2 μM. YM928 blocks AMPA-induced intracellular calcium influx with an IC50 value of 3 μM and antagonizes AMPA-induced inward currents with an IC50 value of 1 μM. YM928 is promising for research of neurological disorders.
-
EMD 21657
0 ImagesCat. No.: HY-114987CAS No.: 61711-37-3EMD 21657 is a derivative of Piracetam (HY-B0585). EMD 21657 inhibits LOT compound action potential, and enhances the local anesthetic effect of Hexanol (HY-W032022). EMD 21657 exhibits hemolytic effect, and can be used in research about alcoholic encephalopathy syndrome.
-
p-fin4
0 ImagesCat. No.: HY-P3355CAS No.: 2883747-74-6p-fin4 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 0.4 μM. p-fin4 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p-fin4 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators.
-
CGP 39551
0 ImagesCat. No.: HY-107703CAS No.: 127910-32-1CGP 39551 is a potent, orally active, competitive N-methyl-D-aspartate (NMDA) receptor antagonist with potent anticonvulsant activity. CGP 39551 shows measurable inhibitory activity at both L-[3H]-glutamate (Ki=8.4 μM).
-
NT 13
0 ImagesCat. No.: HY-P7060CAS No.: 117928-93-5Synonyms: TPPTNT 13 (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide. NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.
-
PMPA (NMDA antagonist)
0 ImagesCat. No.: HY-107698CAS No.: 113919-36-1PMPA (NMDA antagonist) is an NMDA receptor antagonist with Ki values of 0.84, 2.74, 3.53 and 4.16 μM for NR2A, NR2B, NR2C and NR2D, respectively.
-
NMDA receptor modulator 5
0 ImagesCat. No.: HY-143396CAS No.: 2758256-97-0NMDA receptor modulator 5 (Compound 195) is a potent NMDA receptor modulator. NMDA receptor modulator 5 can be used for neurological disorder research.
-
AChE/Aβ-IN-2
0 ImagesCat. No.: HY-155735AChE/Aβ-IN-2 (compound 33) is a potent and orally active inhibitor of acetylcholinesterase (AChE) with IC50 of 135 nM, as well as an antagonist of NMDA receptor (GluN1-1b/GluN2B subunit combination) with IC50 of 5.054 μM. AChE/Aβ-IN-2 also inhibits Aβ aggregation and shows good blood-brain barrier permeability. AChE/Aβ-IN-2 improves cognitive and spatial memory impairment in rats model.
-
CNS0042
0 ImagesCat. No.: HY-183948CAS No.: 2419233-87-5CNS0042 is an allosteric modulator of NMDA receptor. CNS0042 can be used for the research of NMDA receptor-mediated neurological or psychiatric disease.
-
AMPA receptor antagonist-3
0 ImagesCat. No.: HY-145959CAS No.: 923272-18-8AMPA receptor antagonist-3 is an AMPA receptor antagonist extracted from patent US20070027143A1. AMPA receptor antagonist-3 can be used for the research of central nervous system disorders.
-
LSP-GR3
0 ImagesCat. No.: HY-148828CAS No.: 1235945-37-5LSP-GR3 is a novel chemically-modified RNA oligonucleotides, called splice modulating oligomers (SMOs), which potently and specifically modulate GluR alternative splicing to GluR3-flip expression throughout the CNS.
-
(RS)-AMPA hydrochloride
0 ImagesCat. No.: HY-100815ECAS No.: 2922283-04-1Synonyms: (±)-AMPA hydrochloride(RS)-AMPA hydrochloride ((±)-AMPA hydrochloride) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA hydrochloride hydrobromide does not interfere with binding sites for kainic acid or NMDA receptors.
