190842-36-5
Chemical Structure
YM928
- CAS No.: 190842-36-5
- Formula:C14H10ClN3OS
- Molecular Weight:303.77
IUPAC Name: 2-((4-chlorophenyl)(methyl)amino)-4H-pyrido[3,2-e][1,3]thiazin-4-one
InChIKey: RCGOQPBYNHJZCU-UHFFFAOYSA-N
SMILES: O=C1N=C(SC2=NC=CC=C12)N(C)C3=CC=C(C=C3)Cl
Biological Activity: YM928 is an orally active and noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist. YM928 inhibits AMPA receptor-mediated toxicity in primary rat hippocampal cultures with an IC50 value of 2 μM. YM928 blocks AMPA-induced intracellular calcium influx with an IC50 value of 3 μM and antagonizes AMPA-induced inward currents with an IC50 value of 1 μM. YM928 is promising for research of neurological disorders[1].
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YM928 | YM928 is an orally active and noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist. YM928 inhibits AMPA receptor-mediated toxicity in primary rat hippocampal cultures with an IC50 value of 2 μM. YM928 blocks AMPA-induced intracellular calcium influx with an IC50 value of 3 μM and antagonizes AMPA-induced inward currents with an IC50 value of 1 μM. YM928 is promising for research of neurological disorders. | |||||||||||||||||||||
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Keywords
