2. Signaling Pathways
  3. Immunology/Inflammation
  4. MHC
  5. MHC II Isoform
  6. MHC II Activator

MHC II Activator

MHC II Activator (1):

Cat. No. Product Name Effect Purity
  • HY-P992408
    MEDI-5083
    		Activator
    MEDI-5083 is an Fc fusion protein that targets CD40 and is a CD40 agonist. MEDI-5083 stimulates CD40 signaling via NF-κB activation. MEDI-5083 upregulates MHCII, CD80, and CD86 expression, induces pro-inflammatory cytokine secretion, and enhances IFN-γ secretion by memory CD8+ T cells. MEDI-5083 can be used for the research of melanoma, colon carcinoma, and advanced solid tumors[1][2].