2. Signaling Pathways
  3. GPCR/G Protein
  4. Orphan GPCR
  5. Orphan GPCR Inhibitor

Orphan GPCR Inhibitor

Orphan GPCR Inhibitors (8):

Cat. No. Product Name Effect Purity
  • HY-12664
    AF64394
    		Inhibitor 98.02%
    AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.
  • HY-P991805
    Anti-Mouse F4/80 Antibody (Cl:A3-1)
    		Inhibitor
    Anti-Mouse F4/80 Antibody (Cl:A3-1) reacts with the mouse F4/80. The F4/80 receptor is generally considered a murine pan-macrophage marker. Recommend Isotype Controls: Rat IgG2b kappa, Isotype Control (HY-P990682).
  • HY-156354
    GPR61 Inverse agonist 1
    		Inhibitor 98.24%
    GPR61 Inverse agonist 1 (Compound 1) is a GPR61 inverse agonist (IC50: 11 nM). GPR61 Inverse agonist 1 can be used for research of disorders of metabolism and body weight, such as obesity and cachexia.
  • HY-110114
    Gue1654
    		Inhibitor 98.31%
    Gue1654 is a modulator of OXE-R. Gue1654 inhibits Gβγ but not Gα signaling triggered upon activation of Gα(i)-βγ by the chemoattractant receptor OXE-R. Gue1654 does not interfere nonspecifically with signaling directly at or downstream of Gβγ.
  • HY-P991726
    Vemzatatug
    		Inhibitor
    Vemzatatug is a humanized IgG1κ monoclonal antibody inhibitor targeting GPRC5D. Vemzatatug has an antitumor activity. Vemzatatug can be used for cancers like multiple myeloma (MM) research.
  • HY-182271
    GPR61 Inverse agonist 3
    		Inhibitor
    GPR61 Inverse agonist 3 is a selective and brain-penetrant GPR61 inverse agonist with human IC50 of 4.0 nM, mouse IC50 of 8.8 nM, human Ki of 0.34 nM, mouse Ki of 1.1 nM. GPR61 Inverse agonist 3 disrupts GPR61-Gαs protein interactions to abolish GPR61 constitutive activity. GPR61 Inverse agonist 3 moderately inhibits GABAA chloride channel and PDE3A1 with IC50 values of 4.6 and 8.9 μM. GPR61 Inverse agonist 3 shows no functional effect on food intake in adult mice co-administered with a pan-CYP inhibitor. GPR61 Inverse agonist 3 can be used for the research of cachexia/sarcopenia.
  • HY-P991587
    SAR-446523
    		Inhibitor
    SAR-446523 is a humanized IgG1 monoclonal antibody inhibitor targeting GPRC5D. SAR-446523 significantly induces antibody-dependent cell-mediated cytotoxicity (ADCC). SAR-446523 has potent antitumor activity with improvement of mouse survival in NK humanized NOG huIL15 transgenic mice model bearing MM cells. SAR-446523 can be used for multiple myeloma (MM) research.
  • HY-159161
    PSB-CB-27
    		Inhibitor
    PSB-CB-27 is a potent and selective GPR18 inhibitor with an IC50 of 0.65 μM. PSB-CB-27 shows selectivity over Human GPR55, Human CB1 receptor, and Human CB2 receptor. PSB-CB-27 leads to a complete blockade of Δ9-Tetrahydrocannabinol (THC)-induced GPR18 activation. PSB-CB-27 can be used for inflammatory diseases and cancer immunotherapy research.