2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. p97

p97

VCP; Cdc48

p97

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p97 (also referred to as VCP) is a highly conserved and abundant AAA+ (ATPases associated with diverse cellular activities) ATPase that plays an essential role in cellular proteostasis. p97 participates in a large number of important cellular activities, including (i) proteasomal degradation, through its roles in extracting proteins from membranes or molecular complexes; (ii) lysosomal degradation via autophagy and endolysosomal sorting; (iii) membrane fusion; and (iv) regulation of intracellular signaling, cell proliferation, and survival. These diverse cellular functions are powered by the chemical energy from ATP hydrolysis and coordinated through the interaction of p97 with as many as 40 cofactors that recruit it to specific subcellular locations and to designated substrates for their remodeling and processing.

Mutations in p97 have been linked to a number of neurodegenerative diseases, and overexpression of wild type p97 is observed in numerous cancers. Furthermore, p97 activity has been shown to be essential for the replication of certain viruses, including poliovirus, herpes simplex virus (HSV), cytomegalovirus (CMV), and influenza. These observations highlight the potential for targeting p97 as a therapeutic approach in neurodegeneration, cancer, and certain infectious diseases.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-124776
    NPD8733
    		Inhibitor 99.92%
    NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. NPD8733 specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family. NPD8733 has the potential for the research of cancer diseases.
    NPD8733
  • HY-139606
    VCP/p97 inhibitor-1
    		Inhibitor 98.64%
    VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS).
    VCP/p97 inhibitor-1
  • HY-148122
    NW 1028
    		Inhibitor
    NW 1028 is a potent VCP/p97 inhibitor. NW 1028 targets the ND1L domain of p97 and inhibits the degradation of a p97-dependent reporter. NW 1028 has good binding affinity with Kd values of 100 and 285 nM for ND1L and full length p97, respectively. NW 1028 has the function of regulating the mitotic spindle of cells.
    NW 1028
  • HY-174847
    VCP/p97 IN-2
    		Inhibitor
    VCP/p97 IN-2 (Compound V13) is a VCP/p97 inhibitor with IC50 of 32 nM for p97. VCP/p97 IN-2 has excellent antitumor activities and significantly inhibits tumor growth in Molm-13 xenograft mice model. VCP/p97 IN-2 can be used for acute myeloid leukemia (AML) research.
    VCP/p97 IN-2
  • HY-168006
    NSC819701
    		Inhibitor
    NSC819701 is a triazole inhibitor of the p97 ATPase. NSC819701 inhibits the activity of p97 ATPase by binding to a specific site of p97.
    NSC819701
  • HY-174984
    VCP/p97 IN-3
    		Inhibitor
    VCP/p97 IN-3 is a VCP/p97 allosteric inhibitor. VCP/p97 IN-3 shows the inhibitory activity against the VCP proteins with an IC50 of 9 nM and the mutant VCP proteins with IC50 of 12 nM (N660K) and 19 nM (V474A/D649A). VCP/p97 IN-3 increases K48-linked ubiquitination and the level of cleaved caspase-3. VCP/p97 IN-3 activates ER-stress and the UPR. VCP/p97 IN-3 inhibits tumor growth in RPMI-8226 cell subcutaneous xenograft mouse models. VCP/p97 IN-3 can be used for the study of multiple myeloma.
    VCP/p97 IN-3
  • HY-174844
    p97-IN-1
    		Inhibitor
    p97-IN-1 is an orally active p97 inhibitor (IC50 = 26 nM). p97-IN-1 can significantly inhibit the proliferation of tumor cells. p97-IN-1 can be used for research on acute myeloid leukemia (AML).
    p97-IN-1
  • HY-168005
    NSC799462
    		Inhibitor
    NSC799462 is a triazole inhibitor of p97 ATPase. NSC799462 inhibits p97 ATPase activity (IC50 = 15 nM) by binding to a specific site on p97 and causing local changes in the p97 structure.
    NSC799462
  • HY-183920
    LC-1310
    		Inhibitor
    LC-1310 is an antiviral agent that targets and inhibits p97, and it suppresses the in vitro replication of human cytomegalovirus (HCMV) with an EC50 value of 0.3 μM. LC-1310 targets the D2 ATP-binding site of p97, downregulates the expression of early viral proteins, thereby blocking the transcription and proliferation of early viral genes. LC-1310 can be used for research on human cytomegalovirus infection.
    LC-1310
  • HY-179257
    p97-IN-2
    		Inhibitor
    p97-IN-2 (Compound 14) is a p97 ATPase (IC50 = 0.6 μM) inhibitor. p97-IN-2 can inhibit cell proliferation, such as HCT15 (IC50 = 1.1 μM) and SW403 (IC50 = 0.8 μM) cells. p97-IN-2 can be used for cancer research.
    p97-IN-2
  • HY-19795R
    ML240 (Standard)
    		Inhibitor
    ML240 (Standard) is the analytical standard of ML240. This product is intended for research and analytical applications. ML240 is a potent p97 inhibitor, inhibiting p97 ATPase with IC50 value of 100 nM.
    ML240 (Standard)
  • HY-118460
    ACJI-99C
    		Inhibitor
    ACJI-99C (VCP/p97-IN-PPA) is a selective covalent p97/VCP ATPase inhibitor with an IC50 value of 0.6 μM. ACJI-99C binds with p97 active site residues to block ATPase activity. ACJI-99C irreversibly blocks degradation of p97-dependent protein in cells. ACJI-99C inhibits proliferation of cancer cells, including p97 inhibitor-resistant lines. ACJI-99C can be used for the research of colorectal cancer.
    ACJI-99C
Cat. No. Product Name / Synonyms Application Reactivity