2769753-59-3
Chemical Structure
DB-0646
- CAS No.: 2769753-59-3
- Formula:C52H51F3N14O7
- Molecular Weight:1041.05
IUPAC Name: N-(3-(7-((6-(4-((1-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentyl)-1H-1,2,3-triazol-4-yl)methyl)piperazin-1-yl)pyridin-3-yl)amino)-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide
InChIKey: BDNROHBTZXVJDB-UHFFFAOYSA-N
SMILES: O=C(N1C2CCC(NC2=O)=O)C3=C(OCCCCCN4N=NC(CN5CCN(C6=NC=C(NC7=NC=C8C(N(C)C(N(C9=CC(NC(C%10=CC=CC(C(F)(F)F)=C%10)=O)=CC=C9C)C8)=O)=N7)C=C6)CC5)=C4)C=CC=C3C1=O
Biological Activity: DB-0646 is a multi-target PROTAC degrader that degrades over 125 distinct kinases in various cell lines, with its degradation process dependent on the activity of p97. DB-0646 induces ubiquitination and degradation of GCK, BUB1 and YES1[1][2].
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DB-0646 | 98.0% | DB-0646 is a multi-target PROTAC degrader that degrades over 125 distinct kinases in various cell lines, with its degradation process dependent on the activity of p97. DB-0646 induces ubiquitination and degradation of GCK, BUB1 and YES1. | ||||||||||||||||||||
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- [1]. Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183(6):1714-1731.e10. [Content Brief]
- [2]. Zhou M, et al. HUWE1 amplifies ubiquitin modifications to broadly stimulate clearance of proteins and aggregates[J]. BioRxiv, 2023: 2023.05. 30.542866. [Content Brief]
Keywords
