114 Results for "

Uracil

" in MedChemExpress (MCE) Product Catalog:
Products (114)

114 Results for "Uracil" in MCE Product Catalog:

324
5-Fluorouracil
5-Fluorouracil
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324 Publications Verification
Cat. No.: HY-90006
CAS No.: 51-21-8
Synonyms: 5-FU
Category:  

Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:  

Exosomes Nucleoside Antimetabolite/Analog HIV Apoptosis Endogenous Metabolite

5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer . 5-Fluorouracil also inhibits HIV .
19
Uridine
Uridine
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19 Cited Publications
Cat. No.: HY-B1449
CAS No.: 58-96-8
Synonyms: β-Uridine
Category:  

Human Gut Microbiota Metabolites Natural Products Microorganisms Other Diseases Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Nucleoside Antimetabolite/Analog NF-κB

Uridine (β-Uridine) is a nucleoside compound composed of uracil and a ribose ring, which are connected by a β-N1-glycosidic bond .
5
RNase A, Bovine pancreas
RNase A, Bovine pancreas
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5 Cited Publications
Cat. No.: HY-129046
CAS No.: 9001-99-4
Synonyms: Ribonuclease A; EC 4.6.1.18; RNase A
Target:  

Endonuclease DNA/RNA Synthesis

Research Areas:  

Others

RNase A (Bovine pancreatic RNase) is a widely used Endonuclease in DNA purification by specifically hydrolyzing cytosine or uracil residues of RNA. RNase A degrades the RNA in the RNA/DNA duplex. RNase A catalyses the breakdown of 3',5'-phosphodiester linkages of single stranded RNA. RNase A family members in organisms are tightly involved in various physiological and pathological processes including cell growth and development, proliferation, differentiation and migration. Dysregulation of RNase A activity or expression level is closely related to pancreatic, ovarian, bladder and thyroid cancer. RNase A has tumor cell-killing ability .
4
Uracil
Uracil
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4 Cited Publications
Cat. No.: HY-I0960
CAS No.: 66-22-8
Category:  

Human Gut Microbiota Metabolites Natural Products Microorganisms Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer

Target:  

Endogenous Metabolite Drug Derivative

Uracil is a pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. Uracil is a frequently occurring DNA base damage that results from the spontaneous or chemically induced deamination of cytosine and is mutagenic at the level of replication. Uracil could potentially alter transcriptional fidelity, resulting in production of mutant proteins .
2
Tegafur
Tegafur
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2 Cited Publications
Cat. No.: HY-17400
CAS No.: 17902-23-7
Synonyms: FT 207; NSC 148958
Target:  

Nucleoside Antimetabolite/Analog

Research Areas:  

Cancer

Tegafur (FT 207; NSC 148958) is a chemotherapeutic 5-FU proagent used in the treatment of cancers; is a component of tegafur-uracil.
1
Dihydrouracil
Dihydrouracil
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1 Cited Publications
Cat. No.: HY-W012926
CAS No.: 504-07-4
Synonyms: 5,6-DihydroUracil
Category:  

Natural Products Microorganisms Disease markers Metabolic Disease Endocrine diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient .
1
5-Fluorouracil (Standard)
5-Fluorouracil (Standard)
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1 Cited Publications
Cat. No.: HY-90006R
CAS No.: 51-21-8
Synonyms: 5-FU (Standard)
Category:  

Natural Products Endogenous metabolite

Target:  

Reference Standards Exosomes Nucleoside Antimetabolite/Analog HIV Apoptosis Endogenous Metabolite

5-Fluorouracil (Standard) is the analytical standard of 5-Fluorouracil. This product is intended for research and analytical applications. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer . 5-Fluorouracil also inhibits HIV .
1
1-beta-D-Arabinofuranosyluracil
1-beta-D-Arabinofuranosyluracil
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1 Cited Publications
Cat. No.: HY-N6652
CAS No.: 3083-77-0
Synonyms: Uracil 1-β-D-arabinofuranoside
Category:  

Cardiovascular Disease Natural Products Animals Marine natural products Disease Research Fields Inflammation/Immunology

Target:  

Others

1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties . 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells .
1
Pseudouridine 5'-triphosphate trisodium solution (100 mM)
Pseudouridine 5'-triphosphate trisodium solution (100 mM)
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1 Cited Publications
Cat. No.: HY-141567A
Purity:  ≥98.0%
Synonyms: Pseudo-UTP trisodium solution (100 mM)
Pseudouridine 5'-triphosphate (Pseudo-UTP) trisodium solution (100 mM) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate trisodium solution (100 mM) enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate trisodium solution (100 mM) can be used for the research of vaccinia virus infection .
1
Uridine-13C5
Uridine-13C5
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1 Cited Publications
Cat. No.: HY-B1449S10
CAS No.: 159496-16-9
Synonyms: β-Uridine-13C5
Uridine- 13C5 (β-Uridine- 13C5) is a 13C labeled Uridine (HY-B1449). Uridine (β-Uridine) is a nucleoside compound consisting of uracil and a ribose ring, which are linked by a β-N1- glycosyl bond.
1
Uracil-d2
Uracil-d2
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1 Cited Publications
Cat. No.: HY-I0960S4
CAS No.: 24897-52-7
Uracil-d2 is the deuterium labeled Uracil . Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA .
1
4′-Thiouridine
4′-Thiouridine
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1 Cited Publications
Cat. No.: HY-W113081
CAS No.: 6741-73-7
Synonyms: 1-(4-Thio-beta-D-ribofuranosyl)Uracil
Target:  

Nucleoside Antimetabolite/Analog

Research Areas:  

Others

4′-Thiouridine (1-(4-Thio-beta-D-ribofuranosyl)uracil) is a thio analog of thymidine. 4′-Thiouridine can be used to synthesize 4'-thionucleosides with antiviral and anticancer activities. 4′-Thiouridine can be used for RNA-sequencing .
1
N-Carbamoyl-L-aspartic acid
N-Carbamoyl-L-aspartic acid
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1 Cited Publications
Cat. No.: HY-128425A
CAS No.: 13184-27-5
Purity:  ≥98.0%
Synonyms: L-Ureidosuccinic acid
Category:  

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Fungal

N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura + strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura - strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of *Saccharomyces cerevisiae* by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase .
1
5-Methyluridine
5-Methyluridine
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1 Cited Publications
Cat. No.: HY-W009444
CAS No.: 1463-10-1
Category:  

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

5-Methyluridine (m 5U) is an RNA modified nucleotide generated by RNA methyltransferases (such as TrmA and RumA), which mainly targets specific uracil sites in RNA molecules such as the T arm of tRNA and rRNA. 5-Methyluridine relies on enzyme recognition of RNA secondary/tertiary structures (such as the T loop of tRNA or the specific stem-loop structure of rRNA) and participates in physiological processes such as translation accuracy and ribosome function by stabilizing RNA folding or regulating base pairing .
1
3-Methyluridine
3-Methyluridine
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1 Cited Publications
Cat. No.: HY-113138
CAS No.: 2140-69-4
Purity:  99.05%
Synonyms: N3-Methyluridine
Category:  

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

3-Methyluridine (m 3U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance .
Cylindrospermopsin
Cylindrospermopsin
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Cat. No.: HY-121360
CAS No.: 143545-90-8
Category:  

Microorganisms

Target:  

DNA/RNA Synthesis Reactive Oxygen Species (ROS)

Cylindrospermopsin, a cyanotoxin, is a polycyclic uracil derivative containing guanidine and sulfate groups, which can inhibit protein synthesis and covalently modify DNA or RNA. Cylindrospermopsin induces hepatocellular hypertrophy, renal cellular hypertrophy, intracellular reactive oxygen species (ROS), DNA strand breaks, mitochondrial hyperpolarisation, ultrastructural damage, and altered gene expression in liver, kidney, and intestinal cells. Cylindrospermopsin can be used in research including hepatocellular carcinoma and water quality testing .
dUTP trisodium
dUTP trisodium
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Cat. No.: HY-W017068
CAS No.: 102814-08-4
Synonyms: 2'-Deoxyuridine-5'-triphosphate trisodium salt
Target:  

DNA/RNA Synthesis

Research Areas:  

Others

dUTP trisodium (2´-Deoxyuridine, 5´-Triphosphate) is the salt form of dUTP. dUTP is a metabolic intermediate in both procaryotes and eucaryotes. dUTP can be used in PCR and RT-PCR to replace dTTP, resulting in the uracil-containing PCR products suitable for most standard applications. dUTP is found to inhibit the enzyme - Cytidine Aminohydrolase from sheep liver .
2-Aminoadenosine
2-Aminoadenosine
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Cat. No.: HY-W011548
CAS No.: 2096-10-8
Target:  

Nucleoside Antimetabolite/Analog

Research Areas:  

Others

2-Aminoadenosine is a modified adenine base and adenosine analog that stabilizes RNA duplexes and enhances template-directed nucleotide condensation reactions. 2-Aminoadenosine forms three hydrogen bonds with uracil to increase the melting temperature of hybrid strands, thereby stabilizing uracil-containing RNA duplexes .
2,4-Dihydroxypyrimidine-5-carboxylic Acid
2,4-Dihydroxypyrimidine-5-carboxylic Acid
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Cat. No.: HY-66047
CAS No.: 23945-44-0
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Biochemical Assay Reagents

2,4-Dihydroxypyrimidine-5-carboxylic acid (Uracil-5-carboxylic acid) is a linker. 2,4-Dihydroxypyrimidine-5-carboxylic acid can be assembled with various metal ions. 2,4-Dihydroxypyrimidine-5-carboxylic acid can be enzymatically converted to Uracil (HY-I0960) .
3′-Deoxyuridine
3′-Deoxyuridine
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Cat. No.: HY-W012282
CAS No.: 7057-27-4
Target:  

HCV

Research Areas:  

Infection

3′-Deoxyuridine is a 3'-deoxynucleoside analog and a 2',3'-dideoxynucleoside. 3′-Deoxyuridine does not inhibit the replication of HCV-like RNA templates or luciferase levels in human cells at the tested concentrations. 3′-Deoxyuridine serves as a substrate for microbial dideoxyribosylation reactions to generate various 2',3'-dideoxynucleosides, but cannot be converted into 2',3'-dideoxycytidine by resting E. coli AJ 2595 cells. 3′-Deoxyuridine can be formed by the deamination of 3'-deoxycytidine by E. coli BM-11 cytidine deaminase, and can also undergo phosphorolytic cleavage to produce uracil and the corresponding pentose phosphate. 3′-Deoxyuridine has been used in research related to HCV and other relevant fields .
Assay Types