4′-Thiouridine
Based on 1 publication(s) in Google Scholar
4′-Thiouridine (1-(4-Thio-beta-D-ribofuranosyl)uracil) is a thio analog of thymidine. 4′-Thiouridine can be used to synthesize 4'-thionucleosides with antiviral and anticancer activities. 4′-Thiouridine can be used for RNA-sequencing.
For research use only. We do not sell to patients.
- Purity: 98.68%
- CAS No.: 6741-73-7
- Formula: C9H12N2O5S
- Molecular Weight:260.27
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) 4′-Thiouridine
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Biological Activity
4′-Thiouridine (1-(4-thio-beta-D-ribofuranosyl)uracil) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6741-73-7
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Appearance Solid
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Molecular Weight 260.27
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Formula C9H12N2O5S
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Color White to off-white
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SMILES
O=C(N([C@@H]1S[C@H](CO)[C@@H](O)[C@H]1O)C=C2)NC2=O
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Synonyms
1-(4-Thio-beta-D-ribofuranosyl)uracil
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
CANTAC-seq analysis reveals E2f1 and Otx1 coordinate zygotic genome activation in Xenopus tropicalis. [Abstract]2025 Nov 18;16(1):10101. PMID: 41253814
Solvent & Solubility
DMSO : 125 mg/mL (480.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [Content Brief]
[2]. Benckendorff CMM, et al., Preparation of a 4'-Thiouridine Building-Block for Solid-Phase Oligonucleotide Synthesis. Curr Protoc. 2023 Sep;3(9):e878. [Content Brief]
[3]. Garibaldi A, et al., Isolation of Newly Transcribed RNA Using the Metabolic Label 4-Thiouridine. Methods Mol Biol. 2017;1648:169-176. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8422 mL | 19.2108 mL | 38.4216 mL | 96.0541 mL |
| 5 mM | 0.7684 mL | 3.8422 mL | 7.6843 mL | 19.2108 mL | |
| 10 mM | 0.3842 mL | 1.9211 mL | 3.8422 mL | 9.6054 mL | |
| 15 mM | 0.2561 mL | 1.2807 mL | 2.5614 mL | 6.4036 mL | |
| 20 mM | 0.1921 mL | 0.9605 mL | 1.9211 mL | 4.8027 mL | |
| 25 mM | 0.1537 mL | 0.7684 mL | 1.5369 mL | 3.8422 mL | |
| 30 mM | 0.1281 mL | 0.6404 mL | 1.2807 mL | 3.2018 mL | |
| 40 mM | 0.0961 mL | 0.4803 mL | 0.9605 mL | 2.4014 mL | |
| 50 mM | 0.0768 mL | 0.3842 mL | 0.7684 mL | 1.9211 mL | |
| 60 mM | 0.0640 mL | 0.3202 mL | 0.6404 mL | 1.6009 mL | |
| 80 mM | 0.0480 mL | 0.2401 mL | 0.4803 mL | 1.2007 mL | |
| 100 mM | 0.0384 mL | 0.1921 mL | 0.3842 mL | 0.9605 mL |
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