1463-10-1
Chemical Structure
5-Methyluridine
- CAS No.: 1463-10-1
- Formula:C10H14N2O6
- Molecular Weight:258.23
IUPAC Name: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
InChIKey: DWRXFEITVBNRMK-JXOAFFINSA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO
Biological Activity: 5-Methyluridine (m5U) is an RNA modified nucleotide generated by RNA methyltransferases (such as TrmA and RumA), which mainly targets specific uracil sites in RNA molecules such as the T arm of tRNA and rRNA. 5-Methyluridine relies on enzyme recognition of RNA secondary/tertiary structures (such as the T loop of tRNA or the specific stem-loop structure of rRNA) and participates in physiological processes such as translation accuracy and ribosome function by stabilizing RNA folding or regulating base pairing[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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5-Methyluridine | 99.89% | 5-Methyluridine (m5U) is an RNA modified nucleotide generated by RNA methyltransferases (such as TrmA and RumA), which mainly targets specific uracil sites in RNA molecules such as the T arm of tRNA and rRNA. 5-Methyluridine relies on enzyme recognition of RNA secondary/tertiary structures (such as the T loop of tRNA or the specific stem-loop structure of rRNA) and participates in physiological processes such as translation accuracy and ribosome function by stabilizing RNA folding or regulating base pairing. | ||||||||||||||||||||
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5-Methyluridine (Standard) | ≥98% | 5-Methyluridine (Standard) is the analytical standard of 5-Methyluridine. This product is intended for research and analytical applications. 5-Methyluridine is a is an endogenous methylated nucleoside found in human fluids. | ||||||||||||||||||||
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5-Methyluridine-5′-13C | 5-Methyluridine-5′-13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu. | |||||||||||||||||||||
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5-Methyluridine-13C5 | 5-Methyluridine-13C5 is 13C labeled 5-Methyluridine. | |||||||||||||||||||||
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5-Methyluridine-1′-13C | 5-Methyluridine-1′-13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu. | |||||||||||||||||||||
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5-Methyluridine-d4 | 99.96% | 5-Methyluridine-d4 is the deuterium labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human fluids. | ||||||||||||||||||||
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5-Methyluridine-2′-13C | 5-Methyluridine-2′-13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu. | |||||||||||||||||||||
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5-Methyluridine-3′-13C | 5-Methyluridine-3′-13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu. | |||||||||||||||||||||
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References
- [1]. Hur S, et al. Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective. J Biol Chem. 2006 Dec 22;281(51):38969-73. [Content Brief]
- [2]. Jones JD, et al. Conserved 5-methyluridine tRNA modification modulates ribosome translocation. bioRxiv [Preprint]. 2023 Nov 12:2023.11.12.566704. [Content Brief]
- [3]. Yang TH, et al. Intracellular levels of S-adenosylhomocysteine but not homocysteine are highly correlated to the expression of nm23-H1 and the level of 5-methyldeoxycytidine in human hepatoma cells with different invasion activities. Nutr Cancer. 2006;55(2):224-31. [Content Brief]
