Thymine 1-β-D-arabinofuranoside
Based on 1 Customer Validation
Thymine 1-β-D-arabinofuranoside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 605-23-2
- Formula: C10H14N2O6
- Molecular Weight:258.23
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
>1 mM
Compound: 6
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Inhibition of human promyelocytic leukemic cell (HL-60) by XXT-microculture tetrazolium assay
Inhibition of human promyelocytic leukemic cell (HL-60) by XXT-microculture tetrazolium assay
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[PMID: 2033590] |
| HL-60 | IC50 |
>1 mM
Compound: 6
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Inhibition of human promyelocytic leukemic cell (HL-60) trypan blue exclusion assay
Inhibition of human promyelocytic leukemic cell (HL-60) trypan blue exclusion assay
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[PMID: 2033590] |
| KB | IC50 |
>500 μg/mL
Compound: ara-T
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In vitro cytotoxicity against herpes simplex virus type-1 (HSV-1) HF strain in infected KB cells
In vitro cytotoxicity against herpes simplex virus type-1 (HSV-1) HF strain in infected KB cells
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[PMID: 2838633] |
| KB | IC50 |
0.6 μg/mL
Compound: ara-T
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Inhibitory activity against herpes simplex virus type-1 (HSV-1) replication in KB cells
Inhibitory activity against herpes simplex virus type-1 (HSV-1) replication in KB cells
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[PMID: 2838633] |
| OST | IC50 |
0.0062 μM
Compound: Ara-T
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Cytotoxicity against human OST TK- cells expressing HSV1 TK
Cytotoxicity against human OST TK- cells expressing HSV1 TK
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[PMID: 17181158] |
| OST | IC50 |
0.055 μM
Compound: Ara-T
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Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 2.5 uM 1-[6-(triphenylmethoxy)hexyl]thymine
Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 2.5 uM 1-[6-(triphenylmethoxy)hexyl]thymine
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[PMID: 17181158] |
| OST | IC50 |
0.1 μM
Compound: Ara-T
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Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 5 uM 1-[6-(triphenylmethoxy)hexyl]thymine
Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 5 uM 1-[6-(triphenylmethoxy)hexyl]thymine
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[PMID: 17181158] |
| OST | IC50 |
0.12 μM
Compound: Ara-T
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Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 2.5 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine
Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 2.5 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine
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[PMID: 17181158] |
| OST | IC50 |
0.15 μM
Compound: Ara-T
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Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 10 uM 1-[6-(triphenylmethoxy)hexyl]thymine
Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 10 uM 1-[6-(triphenylmethoxy)hexyl]thymine
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[PMID: 17181158] |
| OST | IC50 |
0.24 μM
Compound: Ara-T
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Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 5 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine
Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 5 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine
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[PMID: 17181158] |
| OST | IC50 |
0.37 μM
Compound: Ara-T
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Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 10 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine
Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 10 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine
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[PMID: 17181158] |
Chemical Information
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CAS No. 605-23-2
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Appearance Solid
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Molecular Weight 258.23
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Formula C10H14N2O6
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Color Off-white to light yellow
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SMILES
O[C@H]1[C@H](O)[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thymine 1-β-D-arabinofuranoside Related Classifications
HY-137848 Related Classifications
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