Thymine 1-β-D-arabinofuranoside

Cat. No.: HY-137848 Purity: 98.0%: Data Sheet
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Thymine 1-β-D-arabinofuranoside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

For research use only. We do not sell to patients.

Thymine 1-β-D-arabinofuranoside Chemical Structure

CAS No. : 605-23-2

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	> 1 mM Compound: 6	Inhibition of human promyelocytic leukemic cell (HL-60) by XXT-microculture tetrazolium assay Inhibition of human promyelocytic leukemic cell (HL-60) by XXT-microculture tetrazolium assay	[PMID: 2033590]
HL-60	IC₅₀	> 1 mM Compound: 6	Inhibition of human promyelocytic leukemic cell (HL-60) trypan blue exclusion assay Inhibition of human promyelocytic leukemic cell (HL-60) trypan blue exclusion assay	[PMID: 2033590]
KB	IC₅₀	0.6 μg/mL Compound: ara-T	Inhibitory activity against herpes simplex virus type-1 (HSV-1) replication in KB cells Inhibitory activity against herpes simplex virus type-1 (HSV-1) replication in KB cells	[PMID: 2838633]
KB	IC₅₀	> 500 μg/mL Compound: ara-T	In vitro cytotoxicity against herpes simplex virus type-1 (HSV-1) HF strain in infected KB cells In vitro cytotoxicity against herpes simplex virus type-1 (HSV-1) HF strain in infected KB cells	[PMID: 2838633]
OST	IC₅₀	0.0062 μM Compound: Ara-T	Cytotoxicity against human OST TK- cells expressing HSV1 TK Cytotoxicity against human OST TK- cells expressing HSV1 TK	[PMID: 17181158]
OST	IC₅₀	0.055 μM Compound: Ara-T	Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 2.5 uM 1-[6-(triphenylmethoxy)hexyl]thymine Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 2.5 uM 1-[6-(triphenylmethoxy)hexyl]thymine	[PMID: 17181158]
OST	IC₅₀	0.1 μM Compound: Ara-T	Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 5 uM 1-[6-(triphenylmethoxy)hexyl]thymine Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 5 uM 1-[6-(triphenylmethoxy)hexyl]thymine	[PMID: 17181158]
OST	IC₅₀	0.12 μM Compound: Ara-T	Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 2.5 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 2.5 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine	[PMID: 17181158]
OST	IC₅₀	0.15 μM Compound: Ara-T	Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 10 uM 1-[6-(triphenylmethoxy)hexyl]thymine Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 10 uM 1-[6-(triphenylmethoxy)hexyl]thymine	[PMID: 17181158]
OST	IC₅₀	0.24 μM Compound: Ara-T	Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 5 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 5 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine	[PMID: 17181158]
OST	IC₅₀	0.37 μM Compound: Ara-T	Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 10 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine Cytotoxicity against human OST TK- cells expressing HSV1 TK in presence of 10 uM 1-[6-[1,1-(diphenyl)-1-(4-pyridyl)methoxy]hexyl]thymine	[PMID: 17181158]

Molecular Weight

258.23

Formula

C₁₀H₁₄N₂O₆

CAS No.

605-23-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

O[C@H]1[C@H](O)[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation

Purity: 98.0%

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Data Sheet (269 KB) SDS (393 KB)

COA (253 KB) HNMR (134 KB)

Handling Instructions (2659 KB)

References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [Content Brief]