66-22-8
66-22-8
Chemical Structure
Uracil
- CAS No.: 66-22-8
- Formula:C4H4N2O2
- Molecular Weight:112.09
IUPAC Name: pyrimidine-2,4(1H,3H)-dione
InChIKey: ISAKRJDGNUQOIC-UHFFFAOYSA-N
SMILES: O=C1NC(C=CN1)=O
Biological Activity: Uracil is a pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. Uracil is a frequently occurring DNA base damage that results from the spontaneous or chemically induced deamination of cytosine and is mutagenic at the level of replication. Uracil could potentially alter transcriptional fidelity, resulting in production of mutant proteins[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Uracil | 99.94% | Uracil is a pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. Uracil is a frequently occurring DNA base damage that results from the spontaneous or chemically induced deamination of cytosine and is mutagenic at the level of replication. Uracil could potentially alter transcriptional fidelity, resulting in production of mutant proteins. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Uracil (Standard) | 99.86% | Uracil (Standard) is the analytical standard of Uracil. This product is intended for research and analytical applications. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Uracil-d1 | Uracil-d1 is the deuterium labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Uracil-15N2 | 99.62% | Uracil-15N2 is the 15N labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Uracil-d1-1 | Uracil-d1-1 is the deuterium labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Uracil-13C4,15N2 | 98.0% | Uracil-13C4,15N2 is the 13C and 15N labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Uracil-13C4 | 99.88% | Uracil-13C4 is the 13C labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Uracil-d4 | 99.94% | Uracil-d4 is the deuterium labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Uracil-13C | Uracil-13C is the 13C labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Uracil-d2-1 | 99.97% | Uracil-d2-1 is the deuterium labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Uracil-d2 | 99.87% | Uracil-d2 is the deuterium labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Uracil-13C2,15N2 | Uracil-13C2,15N2 is the 13C-labeled and 15N-labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Pałasz A, et al. In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications. Eur J Med Chem. 2015 Jun 5;97:582-611. [Content Brief]
- [2]. Viswanathan A, et al. Phenotypic change caused by transcriptional bypass of uracil in nondividing cells. Science. 1999 Apr 2;284(5411):159-62. [Content Brief]
- [3]. Visnes T, et al. Uracil in DNA and its processing by different DNA glycosylases. Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):563-8. [Content Brief]
- [4]. Ikenaka K, et al. Effect of uracil on metabolism of 5-fluorouracil in vitro. Gan. 1979 Jun;70(3):353-9. [Content Brief]
- [5]. de Koning HP, et al. A highly selective, high-affinity transporter for uracil in Trypanosoma brucei brucei: evidence for proton-dependent transport. Biochem Cell Biol. 1998;76(5):853-8. [Content Brief]
