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Cat. No.: HY-161350

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ALK/HDAC-IN-1

ALK/HDAC-IN-1 is a dual inhibitor for ALK and HDAC6, with IC₅₀s of 16 nM and 1.03 μM, respectively. ALK/HDAC-IN-1 exhibits antitumor activity.

For research use only. We do not sell to patients.

Formula: C₂₇H₃₁N₅O₄
Molecular Weight:489.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

ALK/HDAC-IN-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

ALK/HDAC-IN-1 is a dual inhibitor for ALK and HDAC6, with IC₅₀s of 16 nM and 1.03 μM, respectively. ALK/HDAC-IN-1 exhibits antitumor activity^[1].

IC₅₀ & Target

HDAC6

1.03 μM (IC₅₀)

HDAC8

1.69 μM (IC₅₀)

HDAC1

10.8 μM (IC₅₀)

HDAC11

16.6 μM (IC₅₀)

All HDAC Isoforms :

In Vitro

ALK/HDAC-IN-1 inihibits proliferations of cancer cells A549, HepG2, MCF7, U87MG and H2228, with IC₅₀s of 0.33, 0.59, 0.55, 0.62 and 0.44 μM, respectively^[1].
ALK/HDAC-IN-1 inihibits CYP450 enzymes CYP2C9 with IC₅₀ of 2.65 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

A549, HepG2, MCF7, U87MG and H2228
Concentration:
Incubation Time:

48 h
Result:

Inhibited proliferations with sub-micromolar level IC50 values.

Western Blot Analysis^[1]

Cell Line:

H2228
Concentration:

2 μM
Incubation Time:

6 h
Result:

Ptomoted acetylation of α-tubulin and histone H3.

In Vivo

ALK/HDAC-IN-1 (0-20 mg/kg, i.p. for 21 days) inhibits tumor growth without significant toxicity in A549 xenografted BALB/c mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

A549 xenografted BALB/c mice^[1]
Dosage:

0-20 mg/kg
Administration:

i.p., once daily for 21 days
Result:

Decrease tumor growth with TGIs of 68% and 85%, with dose of 10 and 20 mg/kg, respectively.

Chemical Information

Molecular Weight 489.57
Formula C₂₇H₃₁N₅O₄
SMILES

O=C(/N=C1N([C@@H]2CC[C@H](C(NC(C)C)=O)CC2)C3=CC=C(/C=C/C(NO)=O)C=C3N/1)C4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang KL, et al., Discovery of novel anaplastic lymphoma kinase (ALK) and histone deacetylase (HDAC) dual inhibitors exhibiting antiproliferative activity against non-small cell lung cancer. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2318645. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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ALK/HDAC-IN-1

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ALK/HDAC-IN-1 Related Classifications

HY-161350 Related Classifications