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Cat. No.: HY-184382

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α-Amylase-IN-15

α-Amylase-IN-15 is a dual inhibitor of α-amylase and α-glucosidase, with IC₅₀ values of 6.7 μM and 18.55 μM, respectively, and a K_i value of 50.9 μM against α-amylase. α-Amylase-IN-15 binds to both free α-amylase and the enzyme-substrate complex. By inhibiting α-glucosidase, α-Amylase-IN-15 achieves dual inhibition of carbohydrate metabolic enzymes. α-Amylase-IN-15 can be used in the research of type 2 diabetes.

For research use only. We do not sell to patients.

Formula: C₂₇H₁₉ClN₂O₃S
Molecular Weight:486.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

α-Amylase-IN-15 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

α-Amylase-IN-15 (5IT (b)) (6.25-50 μM; 10 mins (with enzyme); 10 mins (with starch)) potently inhibits human α-amylase, with an IC₅₀ value of 6.7 μM^[1].
α-Amylase-IN-15 is a mixed inhibitor of human α-amylase, with a K_i of 50.9 μM for binding to the free enzyme and a K_is of 26.33 μM for binding to the enzyme-substrate complex^[1].
α-Amylase-IN-15 (1.562-25 μM; 15 mins (with enzyme); 20 mins (with pNPG)) exhibits inhibitory activity against human α-glucosidase, with an IC₅₀ value of 18.55 μM^[1].
α-Amylase-IN-15 (1.562-25 μM; 24 h) exhibits low cytotoxicity against HEK-293 cells, with 90% cell viability maintained at the concentration of 25 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HEK-293 human embryonic kidney cells
Concentration:

0, 1.562, 3.125, 6.25, 12.5, and 25 μM
Incubation Time:

24 h
Result:

Showed no significant cytotoxicity up to 25 μM, with 90% cell viability observed at the 25 μM concentration.

Chemical Information

Molecular Weight 486.97
Formula C₂₇H₁₉ClN₂O₃S
SMILES

O=C(N(CC(C1=CC=C(Cl)C=C1)=O)C/2=O)SC2=C/C3=CN(CC4=CC=CC=C4)C5=C3C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sruthi K, et al. 2,4-thiazolidinediones as dual-target inhibitors against carbohydrate metabolism enzymes in type 2 diabetes. Bioorganic chemistry. 2026 Jun 09;180:110083. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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