Anti-melanoma agent 1
Based on 1 Customer Validation
Anti-melanoma agent 1 (Compound 5m) is an anti-melanoma agent and induces cell apoptosis.
For research use only. We do not sell to patients.
- Purity: 99.56%
- CAS No.: 2418579-17-4
- Formula: C28H28N2O2
- Molecular Weight:424.53
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Apoptosis Compound Library
HY-L003
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Anti-Cancer Compound Library
HY-L025
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Cell Death Library
HY-L162
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MCE Bioactive Compound Library
HY-L001V
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
1.98 μM
Compound: 5m
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Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
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[PMID: 32216987] |
| SK-MEL-28 | IC50 |
3.3 μM
Compound: 5m
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Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
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[PMID: 32216987] |
| SK-MEL-5 | IC50 |
3.7 μM
Compound: 5m
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Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
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[PMID: 32216987] |
Anti-melanoma agent 1 (Compound 5m) (0-100 μM, 48 h) shows antiproliferative activity against melanoma cells[1].
Anti-melanoma agent 1 (0-10 μM) inhibits colony formation in SK-MEL-28[1].
Anti-melanoma agent 1 (1 and 2 μM) induces cell apoptosis (24 h), arrests cell cycle at G2/M phase (12 h), inhibits cell migration (48 h) and disrupts the cellular microtubule network[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SK-MEL-5, SK-MEL-28 and A375
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Concentration:0-100 μM
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Incubation Time:48 h
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Result:Showed antiproliferative activity with IC50 values of 3.70 ± 0.17, 3.30 ± 0.06 and 1.98 ± 0.10 μM against SK-MEL-5, SK-MEL-28 and A375 cells, respectively.
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Cell Line:SK-MEL-28
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Concentration:1 μM and 2 μM
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Incubation Time:24 h
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Result:Induced cell apoptosis.
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Cell Line:SK-MEL-28
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Concentration:1 μM and 2 μM
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Incubation Time:12 h
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Result:Arrested cell cycle at G2/M phase.
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Cell Line:SK-MEL-28
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Concentration:1 μM and 2 μM
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Incubation Time:48 h
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Result:Inhibited cell migration.
Chemical Information
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CAS No. 2418579-17-4
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Appearance Solid
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Molecular Weight 424.53
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Formula C28H28N2O2
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Color White to off-white
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SMILES
OC(CNCC1=CC=C(C2=CC=CC=C2)C=C1)COC3=CC=CC(NC4=CC=CC=C4)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (235.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3555 mL | 11.7777 mL | 23.5555 mL | 58.8887 mL |
| 5 mM | 0.4711 mL | 2.3555 mL | 4.7111 mL | 11.7777 mL | |
| 10 mM | 0.2356 mL | 1.1778 mL | 2.3555 mL | 5.8889 mL | |
| 15 mM | 0.1570 mL | 0.7852 mL | 1.5704 mL | 3.9259 mL | |
| 20 mM | 0.1178 mL | 0.5889 mL | 1.1778 mL | 2.9444 mL | |
| 25 mM | 0.0942 mL | 0.4711 mL | 0.9422 mL | 2.3555 mL | |
| 30 mM | 0.0785 mL | 0.3926 mL | 0.7852 mL | 1.9630 mL | |
| 40 mM | 0.0589 mL | 0.2944 mL | 0.5889 mL | 1.4722 mL | |
| 50 mM | 0.0471 mL | 0.2356 mL | 0.4711 mL | 1.1778 mL | |
| 60 mM | 0.0393 mL | 0.1963 mL | 0.3926 mL | 0.9815 mL | |
| 80 mM | 0.0294 mL | 0.1472 mL | 0.2944 mL | 0.7361 mL | |
| 100 mM | 0.0236 mL | 0.1178 mL | 0.2356 mL | 0.5889 mL |
Anti-melanoma agent 1 Related Classifications
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