Antiangiogenic agent 9
Antiangiogenic agent 9 is an antiangiogenic agent and also a VEGFR-2 inhibitor. Antiangiogenic agent 9 induces apoptosis of breast cancer cells by activating caspase-3 (apoptosis). Antiangiogenic agent 9 exhibits antiproliferative activity against breast cancer cells. Antiangiogenic agent 9 can be used for the research of breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 3091622-60-2
- Formula: C22H18F3N3O4S
- Molecular Weight:477.46
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
VEGFR2 |
Caspase 3 |
Antiangiogenic agent 9 (Compound 9c) (1-100 μM; 24 h) exerts potent antiproliferative activity against MCF-7 cells (IC50 = 27.24 μM) and MDA-MB-231 cells (IC50 = 25.32 μM)[1].
Antiangiogenic agent 9 (24 h) activates caspase-3 and induces apoptosis in MCF-7 cells[1].
The antiangiogenic agent 9 (100 μg/mL; 24 h) reduces the expression level of VEGF in HUVEC cells (from 89.14% to 57.01%)[1].
Antiangiogenic agent 9 exerts significant antiangiogenic activity in the chick embryo chorioallantoic membrane (CAM) assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF-7 cells and MDA-MB-231 cells
-
Concentration:1, 3, 10, 30, 100 μM
-
Incubation Time:24 h
-
Result:Exerted potent antiproliferative activity against MCF-7 cells (IC50 = 27.24 μM) and MDA-MB-231 cells (IC50 = 25.32 μM).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Wistar (female, 180-230 g)[1]
-
Dosage:5 mg/kg; 50 mg/kg; 300 mg/kg; 2000 mg/kg
-
Administration:p.o.; single dose
-
Result:Recorded zero mortality in all groups during the 14-day observation.
Induced abdominal distension and intermittent body stretching within 48 hours at 2000 mg/kg.
Decreased body weight across 5 mg/kg, 50 mg/kg, 300 mg/kg and 2000 mg/kg groups within 14 days.
Exerted no obvious impacts on food and water intake.
Chemical Information
-
CAS No. 3091622-60-2
-
Molecular Weight 477.46
-
Formula C22H18F3N3O4S
-
SMILES
CC(C=C1)=CC=C1C2=CC=CC=C2C(NNC(NS(C3=CC=C(C(F)(F)F)C=C3)(=O)=O)=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiangiogenic agent 9 Related Classifications
HY-183778 Related Classifications
Powered by Bioz