2. Protein Tyrosine Kinase/RTK Apoptosis
  3. VEGFR Caspase Apoptosis
  4. Antiangiogenic agent 9

Antiangiogenic agent 9 is an antiangiogenic agent and also a VEGFR-2 inhibitor. Antiangiogenic agent 9 induces apoptosis of breast cancer cells by activating caspase-3 (apoptosis). Antiangiogenic agent 9 exhibits antiproliferative activity against breast cancer cells. Antiangiogenic agent 9 can be used for the research of breast cancer.

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Antiangiogenic agent 9

Antiangiogenic agent 9 Chemical Structure

CAS No. : 3091622-60-2

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Antiangiogenic agent 9 Related Antibodies

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Description

Antiangiogenic agent 9 is an antiangiogenic agent and also a VEGFR-2 inhibitor. Antiangiogenic agent 9 induces apoptosis of breast cancer cells by activating caspase-3 (apoptosis). Antiangiogenic agent 9 exhibits antiproliferative activity against breast cancer cells. Antiangiogenic agent 9 can be used for the research of breast cancer[1].

IC50 & Target[1]

VEGFR2

 

Caspase 3

 

In Vitro

Antiangiogenic agent 9 (Compound 9c) (1-100 μM; 24 h) exerts potent antiproliferative activity against MCF-7 cells (IC50 = 27.24 μM) and MDA-MB-231 cells (IC50 = 25.32 μM)[1].
Antiangiogenic agent 9 (24 h) activates caspase-3 and induces apoptosis in MCF-7 cells[1].
The antiangiogenic agent 9 (100 μg/mL; 24 h) reduces the expression level of VEGF in HUVEC cells (from 89.14% to 57.01%)[1].
Antiangiogenic agent 9 exerts significant antiangiogenic activity in the chick embryo chorioallantoic membrane (CAM) assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antiangiogenic agent 9 Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF-7 cells and MDA-MB-231 cells
Concentration: 1, 3, 10, 30, 100 μM
Incubation Time: 24 h
Result: Exerted potent antiproliferative activity against MCF-7 cells (IC50 = 27.24 μM) and MDA-MB-231 cells (IC50 = 25.32 μM).
In Vivo

Antiangiogenic agent 9 (Compound 9c) (5-2000 mg/kg; p.o.; single dose) has an LD50 value greater than 2000 mg/kg in female Wistar rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar (female, 180-230 g)[1]
Dosage: 5 mg/kg; 50 mg/kg; 300 mg/kg; 2000 mg/kg
Administration: p.o.; single dose
Result: Recorded zero mortality in all groups during the 14-day observation.
Induced abdominal distension and intermittent body stretching within 48 hours at 2000 mg/kg.
Decreased body weight across 5 mg/kg, 50 mg/kg, 300 mg/kg and 2000 mg/kg groups within 14 days.
Exerted no obvious impacts on food and water intake.
Molecular Weight

477.46

Formula

C22H18F3N3O4S
CAS No.
SMILES

CC(C=C1)=CC=C1C2=CC=CC=C2C(NNC(NS(C3=CC=C(C(F)(F)F)C=C3)(=O)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antiangiogenic agent 9 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiangiogenic agent 93091622-60-2Antiangiogenic agent9Antiangiogenic agent-9VEGFRCaspaseApoptosisVascular endothelial growth factor receptorcaspase-3female Wistar ratsbreast cancerVEGFR-2anti-angiogenic effectsanti-proliferative activityapoptosisbreast tumour cellsInhibitorinhibitorinhibit

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