ABCB7 Antibody
(Synonyms: ABC7, ABCB7, ATP-binding cassette transporter 7, ABC transporter 7 protein)ABCB7 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ABCB7.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IHC-P, ICC/IF
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
ABCB7 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ABCB7.
-
Host Rabbit
-
Clonality Polyclonal
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 83 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 82 kDa
Synthetic peptide corresponding to the C-term region of human ABCB7.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Livraison
Shipping with blue ice.
Background
-
Function
ABCB7 is an Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis. Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis. In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (By similarity)[1][2][3][4].
-
Subcellular Localization
Mitochondrion inner membrane
-
Isoforms & Post-Translational Modification
ABCB7 has 3 isoforms, O75027-1: amino acid length is 752, molecular weight is 82641 Da (predicted); O75027-2: amino acid length is 753, molecular weight is 82769 Da (predicted); O75027-3: amino acid length is 712, molecular weight is 78160 Da (predicted).ABCB7 存在 3 个异构体，O75027-1：氨基酸个数为 752 个，分子量为 82641 Da (预测)；O75027-2：氨基酸个数为 753 个，分子量为 82769 Da (预测)；O75027-3：氨基酸个数为 712 个，分子量为 78160 Da (预测)。
-
Subunit
Homodimer or heterodimer.
-
SwissProt ID
-
Synonyms
ABC7, ABCB7, ATP-binding cassette transporter 7, ABC transporter 7 protein
Documentation
[1]. Allikmets R, et al. Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A). Hum Mol Genet. 1999 May;8(5):743-9. [Content Brief]
[2]. Cavadini P, et al. RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload. Blood. 2007 Apr 15;109(8):3552-9. [Content Brief]
[3]. Pearson SA, et al. Evolution of the human mitochondrial ABCB7 [2Fe-2S](GS)(4) cluster exporter and the molecular mechanism of an E433K disease-causing mutation. Arch Biochem Biophys. 2021 Jan 15;697:108661. [Content Brief]
[4]. Maio N, et al. Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis. Haematologica. 2019 Sep;104(9):1756-1767. [Content Brief]
Powered by Bioz
