ABCD1/ALD Antibody (YA6452)

Cat. No.: HY-P86759: Data Sheet COA
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ABCD1/ALD Antibody (YA6452) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ABCD1/ALD.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

ABCD1/ALD Antibody (YA6452) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ABCD1/ALD.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 83 kDa;

Observed band size: 75 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P33897

Gene ID

215 [NCBI]

Immunogen

Recombinant protein within Human ABCD1 / ALD aa 596-745 / 745.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:11248239, PubMed:15682271, PubMed:16946495, PubMed:18757502, PubMed:21145416, PubMed:23671276, PubMed:29397936, PubMed:33500543). Coupled to the ATP-dependent transporter activity also has a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (PubMed:29397936, PubMed:33500543). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:21145416, PubMed:23671276). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Also controls the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity)

Subcellular Localization：Peroxisome membrane,Mitochondrion membrane,Lysosome membrane,Endoplasmic reticulum membrane

Expression：Induction: Up-regulated by degradation or export of cholesterol

Subunit：Can form homodimers and heterodimers with ABCD2 and ABCD3

Synonyms

ABC42 antibody; Abcd1 antibody; ABCD1_HUMAN antibody; Adrenoleukodystrophy protein antibody; ALD antibody; Aldgh antibody; ALDP antibody; AMN antibody; ATP binding cassette, sub family D (ALD), member 1 antibody; ATP-binding cassette sub-family D member 1 antibody; ABC42 antibody; Abcd1 antibody; ABCD1_HUMAN antibody; Adrenoleukodystrophy protein antibody; ALD antibody; Aldgh antibody; ALDP antibody; AMN antibody; ATP binding cassette, sub family D (ALD), member 1 antibody; ATP-binding cassette sub-family D member 1 antibody; OTTHUMP00000025960 antibody; OTTMUSP00000019283 antibody; RGD1562128 antibody; RP23 373N8.2 antibody; X linked adrenoleukodystrophy (ALD) gene homolog antibody;

Documentation

Select Batch:

Data Sheet (231 KB) SDS (254 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)