ABDH5 Antibody (YA9638)
(Synonyms: ABHD5; Abhydrolase domain containing 5; CDS; CGI58; IECN2; NCIE2;)ABDH5 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to ABDH5.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, FC
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Reactivity :
Human
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Formulation:
Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:20-100 |
Product Details
ABDH5 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to ABDH5.
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Host Rabbit
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 39 kDa
A synthesized peptide derived from human ABHD5
Affinity purified
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ABDH5 is a Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion (By similarity)[1][2][3].
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Subcellular Localization
Cytoplasm; Lipid droplet; Cytoplasm, cytosol
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Expression
Tissue_Specificity: Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons (at protein level).
Induction: Up-regulated upon keratinocyte differentiation (at protein level). -
Isoforms & Post-Translational Modification
ABDH5 has an amino acid length of 349, molecular weight is 39096 Da.
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Subunit
Interacts with ADRP, PLIN and PNPLA2.
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SwissProt ID
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Synonyms
ABHD5; Abhydrolase domain containing 5; CDS; CGI58; IECN2; NCIE2;
Documentation
References
[1]. Ghosh AK, et al. CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid. J Biol Chem. 2008 Sep 5;283(36):24525-33. [Content Brief]
[2]. Lass A, et al. Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab. 2006 May;3(5):309-19. [Content Brief]
[3]. Akiyama M, et al. CGI-58 is an alpha/beta-hydrolase within lipid transporting lamellar granules of differentiated keratinocytes. Am J Pathol. 2008 Nov;173(5):1349-60. [Content Brief]
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