ACAN Antibody (YA6985)
(Synonyms: ACAN, AGC1, AGCAN, Aggrecan 1, Aggrecan core protein 2)ACAN Antibody (YA6985) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ACAN.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:1000-5000 | 1:100-200 | 1:200-2000 |
Product Details
ACAN Antibody (YA6985) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ACAN.
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Host Rabbit
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Clonality Recombinant
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 250 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 261 kDa
A synthesized peptide derived from human Aggrecan
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ACAN is a This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region
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Subcellular Localization
Secreted, extracellular space, extracellular matrix
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Expression
Tissue_Specificity: Detected in fibroblasts (at protein level) (PubMed:36213313). Restricted to cartilage (PubMed:7524681) -
Isoforms & Post-Translational Modification
P16112 has four isomers: P16112-1: 261329 Da (predicted); P16112-2: 257441 Da (predicted); P16112-3: 250372 Da (predicted); P16112-4: 265340 Da (predicted).
Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides -
Subunit
Forms a complex (via covalent bonds) with MATN1; the interaction increases with age of the organism via an increase in occupancy of MATN1 binding sites (By similarity)
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SwissProt ID
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Synonyms
ACAN, AGC1, AGCAN, Aggrecan 1, Aggrecan core protein 2
Documentation
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