Sarcomeric alpha Actinin Antibody (YA5107)
(Synonyms: ACTN2; Alpha-actinin-2; Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein)Sarcomeric alpha Actinin Antibody (YA5107) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Sarcomeric alpha Actinin.
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Host:
Mouse
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Application:
WB, ICC/IF
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Reactivity :
Human, Rat, Bovine, Chicken, Dog, Pig, Zebrafish
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:100-1:500 |
Product Details
Sarcomeric alpha Actinin Antibody (YA5107) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Sarcomeric alpha Actinin.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Rat, Bovine, Chicken, Dog, Pig, Zebrafish
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Calculated Molecular Weight Predicted band size: 104 kDa;
Purified recombinant human Actinin-α2 (C-terminus) protein fragments expressed in E.coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Sarcomeric alpha Actinin is a F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein
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Subcellular Localization
Cytoplasm, myofibril, sarcomere, Z line
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Expression
Tissue_specificity:It is expressed in both skeletal muscle and cardiac muscle. -
Isoforms & Post-Translational Modification
P35609 has 2 isomers: P35609-1: 103854 Da (predicted); P35609-2: 103920 Da (predicted).
Ubiquitinated by FBXL22, leading to proteasomal degradation -
Subunit
Homodimer; antiparallel. Also forms heterodimers with ACTN3. Interacts with ADAM12, MYOZ1, MYOZ2 and MYOZ3. Interacts via its C-terminal region with the LDB3 PDZ domain. Interacts with XIRP2. Interacts with DST isoform 1 (via N-terminus). Interacts with PARVB. Interacts with SYNPO2
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SwissProt ID
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Synonyms
ACTN2; Alpha-actinin-2; Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein
Documentation
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