Sarcomeric alpha Actinin Antibody (YA5107)

Art. -Nr.: HY-P85415: Data Sheet User Guide for Antibodies
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Sarcomeric alpha Actinin Antibody (YA5107) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Sarcomeric alpha Actinin.

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100 μL		Angebot einholen

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung
Verweise

Beschreibung

Sarcomeric alpha Actinin Antibody (YA5107) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Sarcomeric alpha Actinin.

Host

Mouse

Clonality

Monoclonal

Molekulargewicht

Predicted band size: 104 kDa;

Species Reactivity

Human, Rat, Bovine, Chicken, Dog, Pig, Zebrafish

SwissProt ID

P35609

Gene ID

88 [NCBI]

Immunogen

Purified recombinant human Actinin-α2 (C-terminus) protein fragments expressed in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:2000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-1:500

Reinheit	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified

Appearance

Liquid

Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein

Subcellular Localization：Cytoplasm, myofibril, sarcomere, Z line

Expression：
Tissue_specificity:It is expressed in both skeletal muscle and cardiac muscle.

Isoforms & Post-Translational Modification：P35609 has 2 isomers: P35609-1: 103854 Da (predicted); P35609-2: 103920 Da (predicted).
Ubiquitinated by FBXL22, leading to proteasomal degradation

Subunit：Homodimer; antiparallel. Also forms heterodimers with ACTN3. Interacts with ADAM12, MYOZ1, MYOZ2 and MYOZ3. Interacts via its C-terminal region with the LDB3 PDZ domain. Interacts with XIRP2. Interacts with DST isoform 1 (via N-terminus). Interacts with PARVB. Interacts with SYNPO2

Synonyms

ACTN2; Alpha-actinin-2; Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein

Dokumentation

User Guide for Antibodies (1077 KB)

Verweise

[1]. /biology-dictionary/mda-mb-231-cell.html [Content Brief]