AGTPBP1 Antibody (YA8265)
(Synonyms: CCP1; NNA1)AGTPBP1 Antibody (YA8265) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AGTPBP1.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:1000-4000 | 1:100 |
Product Details
AGTPBP1 Antibody (YA8265) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AGTPBP1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
Human recombinant protein fragment corresponding to amino acids 368-753 of human AGTPBP1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
AGTPBP1 is a Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK. Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis[1][2][3][4].
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Subcellular Localization
Cytoplasm,Cytoplasm, cytosol,Nucleus,Mitochondrion
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Isoforms & Post-Translational Modification
Q9UPW5 has three isomers: Q9UPW5-1: 138448 Da (predicted); Q9UPW5-2: 133864 Da (predicted); Q9UPW5-3: 138647 Da (predicted).
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Subunit
Interacts with MYLK
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SwissProt ID
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Synonyms
CCP1; NNA1
Documentation
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