ALG2 Antibody (YA8333)
(Synonyms: CDGIi; hALPG2; NET38)ALG2 Antibody (YA8333) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ALG2.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
WB, FC
-
Reactivity :
Human
-
Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
FC
FC: Flow Cytometry
|
|---|---|---|
| Dilution Ratio | 1:2000-3000 | 1:100 |
Product Details
ALG2 Antibody (YA8333) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ALG2.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Calculated Molecular Weight Predicted band size: 46.9 kDa
Full length human recombinant protein of human ALG2 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
ALG2 is a Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the second and third mannose residues to the dolichol-linked oligosaccharide chain, to produce Man3GlcNAc(2)-PP-dolichol core oligosaccharide. Man3GlcNAc(2)-PP-dolichol is a substrate for ALG11, the following enzyme in the biosynthetic pathway. While both alpha 1,3 and alpha 1,6 linkages are possible, the sequential addition of alpha 1,3 followed by alpha 1,6 is probably the preferred route[1][2].
-
Subcellular Localization
Endoplasmic reticulum membrane
-
Isoforms & Post-Translational Modification
Q9H553 has two isomers: Q9H553-1: 47092 Da (predicted); Q9H553-2: 37017 Da (predicted).
-
SwissProt ID
-
Synonyms
CDGIi; hALPG2; NET38
Documentation
Powered by Bioz
