Apolipoprotein E Antibody (YA6477)

Cat. No.: HY-P86784: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

Apolipoprotein E Antibody (YA6477) is a Rat -derived and non-conjugated IgG1 monoclonal antibody, targeting to Apolipoprotein E.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Apolipoprotein E Antibody (YA6477) is a Rat -derived and non-conjugated IgG1 monoclonal antibody, targeting to Apolipoprotein E.

Host

Rat

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 36 kDa;

Observed band size: 33 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Mouse, Rat

SwissProt ID

P08226

Gene ID

11816 [NCBI]

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-F IHC-F: Immunohistochemistry-Frozen	1:500
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:2000
WB WB: Western Blot	1:5000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles (By similarity). Finally, APOE also has a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells (PubMed:23676495)

Subcellular Localization：Secreted,Secreted, extracellular space,Secreted, extracellular space, extracellular matrix,Extracellular vesicle,Endosome, multivesicular body

Isoforms & Post-Translational Modification：P08226: 311 amino acids, molecular weight 35867 Da.
N- and O-glycosylated丨Phosphorylated on Tyr-628 and Tyr-644 by SRC; these phosphorylations promote endothelial cell adhesion and migration

Subunit：Homotetramer

Synonyms

AD2 antibody; Apo-E antibody; APOE antibody; APOE_HUMAN antibody; APOEA antibody; Apolipoprotein E antibody; Apolipoprotein E3 antibody; ApolipoproteinE antibody; Apoprotein antibody; LDLCQ5 antibody; AD2 antibody; Apo-E antibody; APOE antibody; APOE_HUMAN antibody; APOEA antibody; Apolipoprotein E antibody; Apolipoprotein E3 antibody; ApolipoproteinE antibody; Apoprotein antibody; LDLCQ5 antibody; LPG antibody;

Documentation

Select Batch:

Data Sheet (231 KB) SDS (254 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)