ARHGEF11 Antibody
(Synonyms: KIAA0380, ARHGEF11, Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF)ARHGEF11 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ARHGEF11.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
ARHGEF11 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ARHGEF11.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
Synthetic peptide corresponding to the N-term region of human ARHGEF11.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ARHGEF11 may play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth
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Subcellular Localization
Cytoplasm; Membrane
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Expression
Tissue_Specificity: Ubiquitously expressed. -
Isoforms & Post-Translational Modification
ARHGEF11 has 2 isoforms, O15085-1: amino acid length is 1522, molecular weight is 167704 Da (predicted); O15085-2: amino acid length is 1562, molecular weight is 172244 Da (predicted).Phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14)
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Subunit
Interacts with GNA12 and GNA13 through the RGS domain.
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SwissProt ID
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Synonyms
KIAA0380, ARHGEF11, Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF
Documentation
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