ATP7B Antibody
(Synonyms: PWD, WC1, WND, ATP7B, Copper-transporting ATPase 2, Copper pump 2, Wilson disease-associated protein)ATP7B Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ATP7B.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:100-500 |
Product Details
ATP7B Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ATP7B.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 157 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 157 kDa
Synthetic peptide corresponding to the N-term region of human ATP7B.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ATP7B is a Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload
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Subcellular Localization
Golgi apparatus, trans-Golgi network membrane; Late endosome
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Expression
Tissue_Specificity: Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues. -
Isoforms & Post-Translational Modification
ATP7B has 5 isoforms, P35670-1: amino acid length is 1465, molecular weight is 157263 Da (predicted); P35670-2: amino acid length is 1258, molecular weight is 133617 Da (predicted); P35670-3: amino acid length is 1354, molecular weight is 145818 Da (predicted); P35670-4: amino acid length is 1447, molecular weight is 155125 Da (predicted); P35670-5: amino acid length is 239, molecular weight is 26021 Da (predicted).Isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form
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Subunit
Monomer.
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SwissProt ID
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Synonyms
PWD, WC1, WND, ATP7B, Copper-transporting ATPase 2, Copper pump 2, Wilson disease-associated protein
Documentation
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