AURKC Antibody (YA8124)(PBS only)
(Synonyms: AIE2; AIK3; ARK3; AurC; aurora-C; HEL-S-90; SPGF5; STK13)AURKC Antibody (YA8124) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AURKC.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
WB, ICC/IF
-
Reactivity :
Human
-
Formulation:
Supplied in PBS, pH 7.4.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:500 | 1:100 |
Product Details
AURKC Antibody (YA8124) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AURKC.
-
Host Mouse
-
Species ReactivityHuman
-
Calculated Molecular Weight Predicted band size: 35.6 kDa
Full-length protein expressed in 293T cell transfected with human AURKC expression vector
Affinity purified
Non-conjugated
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS, pH 7.4.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
AURKC is a Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'
-
Subcellular Localization
Nucleus,Chromosome,Chromosome, centromere,Cytoplasm, cytoskeleton, spindle
-
Expression
Tissue_Specificity: Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase
Induction: Expression is cell cycle-regulated, with an increase during G2 and M phases -
Isoforms & Post-Translational Modification
Q9UQB9 has three isomers: Q9UQB9-1: 35591 Da (predicted); Q9UQB9-2: 32187 Da (predicted); Q9UQB9-3: 33672 Da (predicted).
-
Subunit
Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; predominantly independent AURKB- and AURKC-containing complexes exist; in the complex interacts directly with BIRC5/survivin and INCENP
-
SwissProt ID
-
Synonyms
AIE2; AIK3; ARK3; AurC; aurora-C; HEL-S-90; SPGF5; STK13
Documentation
Powered by Bioz
