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BMP1 Antibody (YA7794)(PBS only)

(Synonyms: OI13; PCOLC; PCP; PCP2; TLD)

BMP1 Antibody (YA7794) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BMP1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    ICC/IF

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • BMP1 Antibody (YA7794)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:100-250

Product Details

Description

BMP1 Antibody (YA7794) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BMP1.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 80.5 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 225-617 of human BMP1 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    BMP1 is a Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular tH2O2bospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation |Plays an important role in bone repair by acting as a coactivator of BMP7[1][2][3][4].

  • Subcellular Localization

    Golgi apparatus, trans-Golgi network,Secreted, extracellular space, extracellular matrix,Secreted,Secreted

  • Expression


    Tissue_Specificity: Ubiquitous

  • Isoforms & Post-Translational Modification

    P13497 has 7 isomers: P13497-1: 111249 Da (predicted); P13497-2: 82900 Da (predicted); P13497-7: Da (predicted); P13497-3: 33424 Da (predicted); P13497-4: 70469 Da (predicted); P13497-5: 81082 Da (predicted); P13497-6: 92655 Da (predicted).
    Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion

  • Subunit

    Interacts with POSTN, the interaction promotes deposition on the extracellular matrix

  • SwissProt ID

    P13497

  • Synonyms

    OI13; PCOLC; PCP; PCP2; TLD

BMP1 Antibody (YA7794)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • BMP1 Antibody (YA7794)(PBS only) Product Image