BMP1 Antibody (YA7794)(PBS only)

製品番号: HY-P88110A: データシート User Guide for Antibodies
FAQs
Technical Support

BMP1 Antibody (YA7794) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BMP1.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量		在庫状況
50 μL		お問い合わせ
100 μL		お問い合わせ

* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

BMP1 Antibody (YA7794) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BMP1.

Host

Mouse

分子量

Predicted band size: 80.5 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P13497

Immunogen

Human recombinant protein fragment corresponding to amino acids 225-617 of human BMP1 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250

純度	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins (PubMed:33206546). Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:32636307, PubMed:33169406). Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers (PubMed:31152061, PubMed:33206546). Additional substrates include matricellular tH2O2bospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (PubMed:32636307)|Plays an important role in bone repair by acting as a coactivator of BMP7

Subcellular Localization：Golgi apparatus, trans-Golgi network,Secreted, extracellular space, extracellular matrix,Secreted,Secreted

Expression：
Tissue_Specificity: Ubiquitous

Isoforms & Post-Translational Modification：P13497 has 7 isomers: P13497-1: 111249 Da (predicted); P13497-2: 82900 Da (predicted); P13497-7: Da (predicted); P13497-3: 33424 Da (predicted); P13497-4: 70469 Da (predicted); P13497-5: 81082 Da (predicted); P13497-6: 92655 Da (predicted).
Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion

Subunit：Interacts with POSTN, the interaction promotes deposition on the extracellular matrix

Synonyms

OI13; PCOLC; PCP; PCP2; TLD

ドキュメンテーション

User Guide for Antibodies (1077 KB)

BMP1 Antibody (YA7794)(PBS only) 関連分類

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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BMP1 Antibody (YA7794)(PBS only)

Product Detail

Background

説明

BMP1 Antibody (YA7794)(PBS only) 関連分類

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