BMP1 Antibody (YA7794)(PBS only)

Cat. No.: HY-P88110A: Data Sheet User Guide for Antibodies
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BMP1 Antibody (YA7794) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BMP1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

BMP1 Antibody (YA7794) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BMP1.

Host

Mouse

Molecular Weight

Predicted band size: 80.5 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P13497

Immunogen

Human recombinant protein fragment corresponding to amino acids 225-617 of human BMP1 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins (PubMed:33206546). Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:32636307, PubMed:33169406). Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers (PubMed:31152061, PubMed:33206546). Additional substrates include matricellular tH2O2bospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (PubMed:32636307)|Plays an important role in bone repair by acting as a coactivator of BMP7

Subcellular Localization：Golgi apparatus, trans-Golgi network,Secreted, extracellular space, extracellular matrix,Secreted,Secreted

Expression：
Tissue_Specificity: Ubiquitous

Isoforms & Post-Translational Modification：P13497 has 7 isomers: P13497-1: 111249 Da (predicted); P13497-2: 82900 Da (predicted); P13497-7: Da (predicted); P13497-3: 33424 Da (predicted); P13497-4: 70469 Da (predicted); P13497-5: 81082 Da (predicted); P13497-6: 92655 Da (predicted).
Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion

Subunit：Interacts with POSTN, the interaction promotes deposition on the extracellular matrix

Synonyms

OI13; PCOLC; PCP; PCP2; TLD

Documentation

User Guide for Antibodies (1077 KB)