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Cat. No.: HY-P87557

BMP11 Antibody (YA7241)

BMP11 Antibody (YA7241) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BMP11.

For research use only. We do not sell to patients.

Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	IHC-F IHC-F: Immunohistochemistry-Frozen	IF-Tissue IF-Tissue: Immunofluorescence-Tissue	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence
Dilution Ratio	1:1000-2000	1:100-200	1:100-200	1:50-200	1:50-200

Description

BMP11 Antibody (YA7241) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BMP11.

Host Rabbit
Clonality Recombinant,Monoclonal
Species Reactivity
Human, Rat
Observed Molecular Weight

Observed band size: 45 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 45 kDa

Immunogen

A synthesized peptide derived from human BMP11

Sensitivity

Endogenous

Purification

affinity purified by Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

BMP11 secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3^[1]^[2].
Subcellular Localization

Secreted
Expression

Tissue_Specificity: In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme
Isoforms & Post-Translational Modification

O95390: 407 amino acids, molecular weight 45091 Da.
Subunit

Homodimer; disulfide-linked (PubMed:26919518, PubMed:31215115)
SwissProt ID

O95390