Yes1 Antibody (YA4808)
(Synonyms: YES1; YES; Tyrosine-protein kinase Yes; Proto-oncogene c-Yes; p61-Yes)Yes1 Antibody (YA4808) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Yes1.
-
Host:
Mouse
-
Application:
WB, ELISA
-
Reactivity :
Human
-
Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:10000 |
Product Details
Yes1 Antibody (YA4808) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Yes1.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Calculated Molecular Weight Predicted band size: 61 kDa;
Purified recombinant fragment of c-Yes (aa10-193) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
Yes1 is a Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity[1].
-
Subcellular Localization
Cell membrane; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytosol; Cell junction
-
Expression
Tissue_specificity:In fetal tissues, this gene is expressed in the epithelial cells of the proximal tubules of the kidneys and the stomach, as well as in hematopoietic cells of the bone marrow and spleen. In humans, this gene is expressed in the epithelial cells of the proximal tubules of the kidneys and is present in keratinocytes of the basal layer of the epidermis. -
Subunit
Interacts with YAP1 and CSF1R (By similarity). Interacts with CTNND1; this interaction allows YES1-mediated activation of FYN and FER and subsequent phosphorylation of CTNND1 (By similarity). Interacts with FASLG. Interacts with IL6ST/gp130 (PubMed:25731159). Interacts with SCRIB, when YES1 is in a closed conformation; the interaction facilitates YES1 autophosphorylation (PubMed:33730553)
-
SwissProt ID
-
Synonyms
YES1; YES; Tyrosine-protein kinase Yes; Proto-oncogene c-Yes; p61-Yes
Documentation
Powered by Bioz
