CBLC Antibody (YA8585)
(Synonyms: CBL-3; CBL-SL; RNF57)CBLC Antibody (YA8585) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CBLC.
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Host:
Mouse
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Isotype:
IgG1
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Application:
FC
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
FC
FC: Flow Cytometry
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|---|---|
| Dilution Ratio | 1:100 |
Product Details
CBLC Antibody (YA8585) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CBLC.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 52.3 kDa
Human recombinant protein fragment corresponding to amino acids 244-474 of human CBLC produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CBLC acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival
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Expression
Tissue_Specificity: Ubiquitous -
Isoforms & Post-Translational Modification
Q9ULV8 has two isomers: Q9ULV8-1: 52456 Da (predicted); Q9ULV8-2: 47418 Da (predicted).
Phosphorylated on multiple tyrosine residues by SRC丨Autoubiquitinated when phosphorylated at Tyr-341, enhanced by SRC; suggesting proteasomal degradation -
Subunit
Interacts with ubiquitin-conjugating enzyme E2 UBE2D2 and UBE2D3
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SwissProt ID
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Synonyms
CBL-3; CBL-SL; RNF57
Documentation
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