CBX2 Antibody (YA9781)
(Synonyms: Chromobox protein homolog 2, CBX2)CBX2 Antibody (YA9781) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to CBX2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat, Rabbit, Monkey
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:200-1000 | 1:200-1000 | 1:200-400 | 1:10000 |
Product Details
CBX2 Antibody (YA9781) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to CBX2.
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Host Rabbit
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat, Rabbit, Monkey
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Calculated Molecular Weight Predicted band size: 56 kDa;
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CBX2 is a Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression[1][2].
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Subcellular Localization
Nucleus; Chromosome
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Isoforms & Post-Translational Modification
CBX2 has 2 isoforms, Q14781-1: amino acid length is 532, molecular weight is 56081 Da (predicted); Q14781-2: amino acid length is 211, molecular weight is 23312 Da (predicted).
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Subunit
Component of a PRC1-like complex.
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SwissProt ID
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Synonyms
Chromobox protein homolog 2, CBX2
Documentation
[1]. Vandamme J, et al. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol Cell Proteomics. 2011 Apr;10(4):M110.002642. [Content Brief]
[2]. Biason-Lauber A, et al. Ovaries and female phenotype in a girl with 46,XY karyotype and mutations in the CBX2 gene. Am J Hum Genet. 2009 May;84(5):658-63. [Content Brief]
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