CD105 Antibody (YA4773)
(Synonyms: ENG; END; Endoglin; CD antigen CD105)CD105 Antibody (YA4773) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD105.
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Host:
Mouse
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Application:
WB, IHC-P, ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
CD105 Antibody (YA4773) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD105.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 71 kDa;
Purified recombinant fragment of human CD105 expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD105 (Endoglin, ENG) is a TGF-β receptor accessory protein primarily expressed on mesenchymal stem cells and activated endothelial cells; it serves as a classic positive marker for the identification of mesenchymal stem cells (MSCs) and is a key target in research concerning angiogenesis, tumor neovascularization, and fibrosis.
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Detected in umbilical cord membrane endothelial cells (PubMed: 10625079) . Detected in the placenta (protein level) (PubMed: 1692830) . Detected in endothelial cells (PubMed: 1692830) . -
Isoforms & Post-Translational Modification
CD105 has 2 isomers: P17813-1: 70578 Da (predicted); P17813-2: 67542 Da (predicted).
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Subunit
Homodimer; disulfide-linked. Forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGFB1 and TGFB2 with high affinity, but not TGFB3. Interacts with GDF2, forming a heterotetramer with a 2:2 stoichiometry. Interacts with ACVRL1. Can form a heteromeric complex with GDF2 and ACVRL1. Interacts with BMP10. Interacts with DYNLT4. Interacts with ARRB2
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SwissProt ID
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Synonyms
ENG; END; Endoglin; CD antigen CD105
Documentation
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