2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. CD133 Antibody (YA809)

CD133 Antibody (YA809) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD133.

For research use only. We do not sell to patients.

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20 μL Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
50 μL Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
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250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

CD133 Antibody (YA809) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD133.
Host

Mouse
Clonality

Monoclonal
Molecular Weight
Predicted band size: 97 kDa;
Observed band size: 133 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Synthetic peptide corresponding to Human Prominin-1.The exact sequence is proprietary to MCE.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity affinity purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG2b  
Appearance

Liquid
Formulation

Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439)
Subcellular Localization：Apical cell membrane; Multi-pass membrane protein; Cell projection, microvillus membrane; Multi-pass membrane protein; Cell projection, cilium, photoreceptor outer segment; Endoplasmic reticulum; Endoplasmic reticulum-Golgi intermediate compartment
Expression：
Tissue_specificity:Isomer 1 is selectively expressed on CD34+ hematopoietic stem cells and progenitor cells in human bone marrow, fetal liver, umbilical cord blood, and human peripheral blood. Isomer 1 is not detected in other blood cells. Isomer 1 is also expressed in a variety of non-lymphoid tissues, including the retina, pancreas, placenta, kidney, liver, lung, brain, and heart. In saliva, isomer 1 exists as small membrane granules. Isomer 2 is primarily expressed in fetal liver, skeletal muscle, kidney, and heart, as well as in human pancreas, kidney, liver, lung, and placenta. Isomer 2 is highly expressed in fetal liver, lowly expressed in bone marrow, and almost undetectable in peripheral blood. Isomer 2 is expressed on hematopoietic stem cells and epidermal basal cells (protein level) . In the human retina, isomer 2 is expressed by rod cells and cone cells (protein level) .
Isoforms & Post-Translational Modification：O43490 has 7 isomers: O43490-1: 97202 Da (predicted); O43490-2: 96251 Da (predicted); O43490-3: 93270 Da (predicted); O43490-4: 93654 Da (predicted); O43490-5: 92741 Da (predicted); O43490-6: 93692 Da (predicted); O43490-7: 94605 Da (predicted).
Isoform 1 and isoform 2 are glycosylated;Acetylation at Lys-225, Lys-257 and Lys-264 by NAT8 and NAT8B may control PROM1 protein expression and its function in cell apoptosis
Subunit：Interacts with CDHR1 and with actin filaments. Interacts with NAT8 and NAT8B
Database

Entrez Gene: 8842 Human

SwissProt: O43490 Human

OMIM: 612095 Human

Research Field

Neuroscience
Synonyms
Prominin-1; Antigen AC133; Prominin-like protein 1; CD133.
Documentation
User Guide for Antibodies (1077 KB)

CD133 Antibody (YA809) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CD133 Antibody (YA809)
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