CD169 Antibody (YA1260)(PBS only)
(Synonyms: SIGLEC1; SN; Sialoadhesin; Sialic acid-binding Ig-like lectin 1 (Siglec-1); CD169)CD169 Antibody (YA1260) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD169.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
CD169 Antibody (YA1260) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD169.
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 220 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 183 kDa
A synthesized peptide derived from human CD169
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD169 is a Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response. Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2. Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination; (Microbial infection) Facilitates viral cytoplasmic entry into activated dendritic cells via recognition of sialylated gangliosides pesent on viral membrane[1][2][3][4][5].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Secreted
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Expression
Tissue_specificity:This gene is expressed in macrophages in various tissues. It is found in higher concentrations in macrophages of the spleen, lymph nodes, and perivascular macrophages of the brain, and in lower concentrations in bone marrow, Kupffer cells of the liver, colon, and lamina propria of the lungs. Inflammatory macrophages in rheumatoid arthritis also express this gene.
Induction:By interferon-alpha (PubMed:28129379) . By viral infection (PubMed:26358190) -
Isoforms & Post-Translational Modification
Q9BZZ2 has 3 isomers: Q9BZZ2-1: 182624 Da (predicted); Q9BZZ2-2: 175727 Da (predicted); Q9BZZ2-3: 181733 Da (predicted).
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Subunit
Interacts with TYROBP. Interacts with CLEC10A (By similarity)
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SwissProt ID
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Synonyms
SIGLEC1; SN; Sialoadhesin; Sialic acid-binding Ig-like lectin 1 (Siglec-1); CD169
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Research Field
Immunology
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