CD169 Antibody (YA1260)(PBS only)

Cat. No.: HY-P81515A: Data Sheet User Guide for Antibodies
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CD169 Antibody (YA1260) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD169.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

CD169 Antibody (YA1260) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD169.

Host

Rabbit

분자량

Predicted band size: 183 kDa;

Observed band size: 220 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q9BZZ2

Gene ID

6614 [NCBI]

Immunogen

A synthesized peptide derived from human CD169

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response (PubMed:12940982, PubMed:33489013). Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs) (PubMed:28129379). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2 (PubMed:28129379, PubMed:34782760). Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid (PubMed:12940982). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination (PubMed:26358190); (Microbial infection) Facilitates viral cytoplasmic entry into activated dendritic cells via recognition of sialylated gangliosides pesent on viral membrane

Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Secreted

Expression：
Tissue_specificity:This gene is expressed in macrophages in various tissues. It is found in higher concentrations in macrophages of the spleen, lymph nodes, and perivascular macrophages of the brain, and in lower concentrations in bone marrow, Kupffer cells of the liver, colon, and lamina propria of the lungs. Inflammatory macrophages in rheumatoid arthritis also express this gene.

Induction:By interferon-alpha (PubMed:28129379) . By viral infection (PubMed:26358190)

Isoforms & Post-Translational Modification：Q9BZZ2 has 3 isomers: Q9BZZ2-1: 182624 Da (predicted); Q9BZZ2-2: 175727 Da (predicted); Q9BZZ2-3: 181733 Da (predicted).

Subunit：Interacts with TYROBP. Interacts with CLEC10A (By similarity)

Research Field

Immunology

Synonyms

SIGLEC1; SN; Sialoadhesin; Sialic acid-binding Ig-like lectin 1 (Siglec-1); CD169

각종 서류

User Guide for Antibodies (1077 KB)