SIGLEC1 - sialic acid binding Ig like lectin 1 Gene

Also Known as SN; CD169; SIGLEC-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6614

About SIGLEC1

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,686,970-3,712,600 (from NCBI)

This gene has 2 transcripts (splice variants), 135 orthologues and 16 paralogues. Broad expression in placenta (RPKM 8.2), spleen (RPKM 6.4) and 20 other tissues.

Summary

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. The protein plays an important role in multiple human diseases and Bacterial and viral infections has been shown to enhance SARS-CoV-2 Infection. [provided by RefSeq, Dec 2021]

SIGLEC1 Products (2)

mRNA Protein Name
NM_001367089.1 NP_001354018.1 sialoadhesin isoform 2 precursor
NM_023068.4 NP_075556.1 sialoadhesin isoform 1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in negative regulation of type I interferon production IDA
IDA: Inferred from direct assay
26358190 GOA
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
28129379 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIGLEC1 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (23 - 135)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (142 - 227)

Ig_2

Ig_2: Immunoglobulin domain (245 - 323)

Ig_2

Ig_2: Immunoglobulin domain (332 - 408)

I-set

I-set: Immunoglobulin I-set domain (424 - 505)

Ig_2

Ig_2: Immunoglobulin domain (516 - 594)

Ig_2

Ig_2: Immunoglobulin domain (616 - 702)

Ig_2

Ig_2: Immunoglobulin domain (714 - 792)

Ig_2

Ig_2: Immunoglobulin domain (809 - 887)

Ig_2

Ig_2: Immunoglobulin domain (899 - 970)

I-set

I-set: Immunoglobulin I-set domain (1003 - 1081)

Ig_2

Ig_2: Immunoglobulin domain (1094 - 1168)

Ig_2

Ig_2: Immunoglobulin domain (1192 - 1256)

Ig_2

Ig_2: Immunoglobulin domain (1266 - 1342)

Ig_2

Ig_2: Immunoglobulin domain (1356 - 1436)

Ig_2

Ig_2: Immunoglobulin domain (1450 - 1529)

Ig_2

Ig_2: Immunoglobulin domain (1547 - 1625)

  • 0
  • 300
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  • 1500
  • 1709 a.a.
Protein Preferred Names Protein Names

sialoadhesin

  • sialic acid binding Ig-like lectin 1, sialoadhesin

Recombinant SIGLEC1 Proteins

Cat. No. Product Name Accession Purity
HY-P78743 Siglec-1/CD169 Protein, Human (HEK293, His) Q9BZZ2-1 (S20-Q1641) ≥ 95%, as determined by reducing SDS-PAGE.

SIGLEC1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81515 CD169 Antibody (YA1260) IHC-P Human
HY-P81515A CD169 Antibody (YA1260)(PBS only) IHC-P Human
HY-P81548 CD169 Antibody (YA1293) WB, FC Human, Mouse
HY-P84780 CD169 Antibody (YA4477) ICC/IF, FC, ELISA Human
HY-P84780A CD169 Antibody (YA4477)(PBS only) ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Heart Block, Congenital

  • Congenital Heart Block

  • Heart Block Congenital

  • Congenital Atrioventricular Block
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12897 SIGLEC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18016 Siglec1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24489 Siglec1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SIGLEC1 VGNC VGNC:34617
Rattus norvegicus SIGLEC1 RGD RGD:1311953
Macaca mulatta SIGLEC1 VGNC VGNC:77220
Felis catus SIGLEC1 VGNC VGNC:65141
Mus musculus SIGLEC1 MGD MGI:1921304
Canis familiaris SIGLEC1 VGNC VGNC:46168
Others SIGLEC1 NCBI