CD239 Antibody (YA4065)(PBS only)

Cat. No.: HY-P84368A: Data Sheet User Guide for Antibodies
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CD239 Antibody (YA4065) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CD239.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CD239 Antibody (YA4065) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CD239.

Host

Mouse

Molecular Weight

Predicted band size: 67.4 kDa;

Observed band size: 85 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P50895

Gene ID

4059 [NCBI]

Immunogen

Purified recombinant fragment of human CD239 (AA: extra 32-197) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion (PubMed:9616226, PubMed:31413112). Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction (PubMed:17158232). Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion (PubMed:15975931). Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR (PubMed:23160466)

Subcellular Localization：Cell membrane; Single-pass type I membrane protein

Expression：
Tissue_specificity:It has a wide distribution in various tissues (highest concentration in the pancreas, extremely low concentration in brain tissue) . It is closely related to the basal layer of epithelial cells and the endothelial cells of blood vessel walls.

Subunit：Homodimer (PubMed:31413112). Interacts with ITGA4:ITGB1 (PubMed:17158232). Interacts with spectrins SPTA1 and SPTB1

Synonyms

BCAM; AU; LU; MSK19

Documentation

User Guide for Antibodies (1077 KB)