CD276/B7H3 Antibody (YA4675)

Cat. No.: HY-P84983: Data Sheet User Guide for Antibodies
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CD276/B7H3 Antibody (YA4675) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD276/B7H3.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CD276/B7H3 Antibody (YA4675) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD276/B7H3.

Host

Mouse

Clonality

Monoclonal

Species Reactivity

Human

SwissProt ID

Q5ZPR3

Gene ID

80381 [NCBI]

Immunogen

Purified recombinant Human CD276

Application &
Dilution Ratio

Application	Dilution Ratio
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:5000-100000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified

Appearance

Liquid

Formulation

Supplied in Phosphate-buffered solution.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling

Subcellular Localization：Membrane; Single-pass type I membrane protein

Expression：
Tissue_specificity:It is ubiquitous but undetectable in peripheral blood lymphocytes or granulocytes. It is weakly expressed in resting monocytes. It is expressed in monocyte-derived dendritic cells. It is expressed in sinus epithelial cells. It is expressed in extravillous trophoblast cells and Hofbauer cells of the placenta in early pregnancy and at term.

Induction:By bacterial lipopolysaccharides (LPS) in monocytes and by ionomycin in T and B-lymphocytes. Up-regulated in cells mediating rejection of human transplants

Isoforms & Post-Translational Modification：Q5ZPR3 has 4 isomers: Q5ZPR3-1: 57235 Da (predicted); Q5ZPR3-2: 33791 Da (predicted); Q5ZPR3-3: 52761 Da (predicted); Q5ZPR3-4: 57165 Da (predicted).

Subunit：Interacts with TREML2 and this interaction enhances T-cell activation

Synonyms

CD276; B7H3; PSEC0249; CD276 antigen; 4Ig-B7-H3; B7 homolog 3; B7-H3; Costimulatory molecule; CD antigen CD276; CD276 nanobody; B7H3 nanobody;

Documentation

User Guide for Antibodies (1077 KB)