CD55 Antibody (YA2440)
(Synonyms: CD55; CR; DAF; Complement decay-accelerating factor; CD55)
Based on 1 Customer Validation
CD55 Antibody (YA2440) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD55.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
CD55 Antibody (YA2440) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD55.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 78 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 41 kDa
A synthetic peptide of human CD55
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD55 is a This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage; (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5; (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable); (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21[1][2].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Cell membrane; Lipid-anchor, GPI-anchor; Secreted; Secreted; Secreted; Cell membrane; Lipid-anchor, GPI-anchor; Cell membrane; Lipid-anchor, GPI-anchor
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Expression
Tissue_specificity:This molecule is expressed on the plasma membrane of all cell types that are in close contact with plasma complement proteins. It is also present on the surface of extracellular interstitial epithelial cells, and variants of this molecule are found in body fluids and the extracellular matrix. -
Isoforms & Post-Translational Modification
P08174 has 7 isomers: P08174-1: 41400 Da (predicted); P08174-2: 48717 Da (predicted); P08174-3: 41900 Da (predicted); P08174-4: 39759 Da (predicted); P08174-5: 48513 Da (predicted); P08174-6: 56218 Da (predicted); P08174-7: 59038 Da (predicted).
The Ser/Thr-rich domain is heavily O-glycosylated -
Subunit
Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form). Interacts with ADGRE5 (PubMed:11297558)
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SwissProt ID
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Synonyms
CD55; CR; DAF; Complement decay-accelerating factor; CD55
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Research Field
Immunology
Documentation
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Data Sheet (234 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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User Guide for Antibodies (1077 KB)
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